Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | RET | P07949 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4168482 | 0.77 | NR3C1 (0.42) | NR3C1PGRNR3C2ARMAPT | |
| SCHEMBL4163483 | 0.74 | NR3C1 (0.42) | NR3C1PGRNR3C2ARCYP3A4 | |
| SCHEMBL4163517 | 0.71 | TSHR (0.40) | NR3C1PGRNR3C2ARCYP3A4 | |
| SCHEMBL4160618 | 0.69 | MAPT (0.56) | NR3C1PGRNR3C2ARCYP3A4 | |
| SCHEMBL4167052 | 0.68 | NPC1 (0.46) | NR3C1PGRNR3C2ARCYP3A4 | |
| SCHEMBL4167049 | 0.68 | NPC1 (0.46) | NR3C1PGRNR3C2ARCYP3A4 | |
| SCHEMBL4161295 | 0.68 | KMT2A (0.44) | ALDH1A1SMN1; SMN2KMT2ALMNAMEN1 | |
| SCHEMBL4175519 | 0.68 | NR3C1 (0.39) | NR3C1PGRNR3C2ARCYP3A4 | |
| SCHEMBL8352573 | 0.67 | RAB9A (0.38) | NR3C1PGRNR3C2ARCYP3A4 | |
| SCHEMBL4157508 | 0.64 | NR3C1 (0.49) | NR3C1PGRNR3C2ARCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052847-A2 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-06-24 | — | — | WO | disclosed |