Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.67 |
| ▸ | HPGD | P15428 | 6/20 | 0.67 |
| ▸ | TP53 | P04637 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 6/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | KLK7 | P49862 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496122 | 0.88 | KDM4E (0.61) | ALDH1A1KDM4EHPGDTP53SMN1; SMN2 | |
| SCHEMBL1251122 | 0.88 | ALDH1A1 (0.65) | ALDH1A1KDM4EHPGDTP53SMN1; SMN2 | |
| SCHEMBL13203469 | 0.87 | ALDH1A1 (0.67) | ALDH1A1KDM4EHPGDTP53SMN1; SMN2 | |
| SCHEMBL13679600 | 0.86 | ADORA2A (0.69) | ALDH1A1KDM4EHPGDTP53SMN1; SMN2 | |
| SCHEMBL26551812 | 0.84 | ALDH1A1 (0.83) | ALDH1A1KDM4EHPGDTP53SMN1; SMN2 | |
| SCHEMBL13203481 | 0.83 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDTP53SMN1; SMN2 | |
| SCHEMBL1899066 | 0.81 | AURKA (0.64) | ALDH1A1KDM4EHPGDTP53SMN1; SMN2 | |
| SCHEMBL2244714 | 0.81 | HPSE (0.79) | ALDH1A1KDM4EHPGDTP53SMN1; SMN2 | |
| SCHEMBL14090191 | 0.81 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDTP53SMN1; SMN2 | |
| SCHEMBL2244254 | 0.81 | KDM4E (1.00) | ALDH1A1KDM4EHPGDTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482373-B2 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482373-B2 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20070027200-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2007-02-01 | — | — | US | disclosed |
| US-20070027200-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2007-02-01 | — | — | US | disclosed |
| WO-2003094861-A2 | BIS-BENZIMIDAZOLES AND RELATED COMPOUNDS AS POTASSIUM CHANNEL MODULATORS | ICAGEN, INC. (US) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027200-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNA3, KCNB2 | ALDH1A1 2373/4885KDM4E 488/4885HPGD 3236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.