Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8352834 | 0.86 | ALDH1A1 (0.67) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4496122 | 0.82 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2244714 | 0.80 | HPSE (0.79) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2244254 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2784089 | 0.78 | RAB9A (0.67) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1899066 | 0.78 | AURKA (0.64) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7396100 | 0.77 | AMY1A (0.64) | ADORA2AKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL16142437 | 0.77 | F2 (0.62) | ADORA2AKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL29595013 | 0.77 | F2 (0.62) | ADORA2AKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL31429745 | 0.77 | F2 (0.62) | ADORA2AKDM4EALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |