Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.65 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8352126 | 0.81 | GRM5 (0.65) | GRM5CSF1RMAPK14HPGDMAPK1 | |
| SCHEMBL8349797 | 0.80 | PTPN1 (0.52) | MAPK14KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL8349130 | 0.79 | MAPK14 (0.52) | GRM5MAPK14HPGDALDH1A1MEN1 | |
| SCHEMBL14348411 | 0.79 | GRM5 (0.56) | GRM5CSF1RHPGDMAPK1ATR | |
| SCHEMBL8351530 | 0.75 | MAPK10 (0.56) | GRM5MAPK14 | |
| SCHEMBL8351194 | 0.75 | MAPK14 (0.55) | MAPK14HPGDMAPK1ALDH1A1RAB9A | |
| SCHEMBL2906631 | 0.71 | PLA2G7 (0.62) | MAPK14HPGDMAPK1ALDH1A1POLB | |
| SCHEMBL8351620 | 0.71 | HPGD (0.57) | GRM5HPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL22575077 | 0.70 | GRM5 (0.62) | GRM5HPGDMAPK1KDM4EALDH1A1 | |
| SCHEMBL14348405 | 0.70 | CAMK2D (0.68) | GRM5HPGDMAPK1ATRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |