Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | GLA | P06280 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | IKBKB | O14920 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NCF1 | P14598 | 1/20 | 0.51 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3219464 | 0.80 | KDM4E (0.52) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL8352155 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL4865999 | 0.77 | NCF1 (0.61) | KDM4EALDH1A1HPGDGLAPOLB | |
| SCHEMBL11549068 | 0.77 | IKBKB (0.59) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL11549035 | 0.76 | IKBKB (0.63) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL11548569 | 0.76 | IKBKB (0.63) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL7508287 | 0.75 | KDM4E (0.60) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL6827783 | 0.75 | KDM4E (0.60) | KDM4EALDH1A1HPGDGLAPOLB | |
| SCHEMBL22279074 | 0.75 | KDM4E (0.60) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL12478522 | 0.75 | NCF1 (0.54) | KDM4EALDH1A1HPGDGLAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908930-A | 5,10-dihydropyrimdo 4,5-b!quinolin-4(1H)-one tyrosine kinase inhibitors | PFIZER INC. (US) | 1999-06-01 | — | — | US | disclosed |
| WO-1996028444-A1 | 5,10-DIHYDROPYRIMIDO[4,5-b]QUINOLIN-4(1H)-ONE TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1996-09-19 | — | — | WO | disclosed |
| US-4134981-A | ANTIALLERGENS | PFIZER INC. (US) | 1979-01-16 | — | — | US | disclosed |
| US-4120962-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1978-10-17 | — | — | US | disclosed |
| US-4044134-A | FUSED WITH QUINOLINE OR PYRIDINE, 2-METHYL, ETHYL, OR ACETYL GROUP | PFIZER INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3974161-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1976-08-10 | — | — | US | disclosed |