Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350635 | 0.90 | MAPT (0.58) | ALDH1A1MAPTLMNAKDM4EPOLB | |
| SCHEMBL8357900 | 0.88 | MAPT (0.55) | ALDH1A1MAPTLMNAKDM4EPOLB | |
| Glyoxylate SCHEMBL8513757 | 0.88 | MAPT (0.57) | ALDH1A1MAPTLMNAKDM4EPOLB | |
| SCHEMBL8358090 | 0.87 | MAPT (0.54) | ALDH1A1MAPTLMNAKDM4EPOLB | |
| SCHEMBL8356273 | 0.87 | MAPT (0.54) | ALDH1A1MAPTLMNAKDM4EPOLB | |
| SCHEMBL8350678 | 0.86 | MMP2 (0.65) | ALDH1A1LMNAMMP2MMP8TSHR | |
| SCHEMBL8358197 | 0.85 | ALDH1A1 (0.61) | ALDH1A1MAPTLMNAKDM4EPOLB | |
| SCHEMBL8353638 | 0.85 | MAPT (0.52) | ALDH1A1MAPTLMNAKDM4EPOLB | |
| SCHEMBL8351096 | 0.80 | MAPT (0.66) | ALDH1A1MAPTLMNAKDM4EPOLB | |
| SCHEMBL8513755 | 0.79 | MAPT (0.55) | ALDH1A1MAPTLMNAKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | claimed |
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |