Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 16/20 | 0.43 |
| ▸ | TMPRSS6 | Q8IU80 | 10/20 | 0.43 |
| ▸ | TMPRSS11D | O60235 | 5/20 | 0.43 |
| ▸ | F10 | P00742 | 4/20 | 0.41 |
| ▸ | PLG | P00747 | 3/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358012 | 0.88 | F2 (0.52) | F2TMPRSS6TMPRSS11DF10PLG | |
| SCHEMBL8345195 | 0.86 | F2 (0.49) | F2TMPRSS6TMPRSS11DF10PLG | |
| SCHEMBL8358318 | 0.81 | F2 (0.51) | F2TMPRSS6TMPRSS11DF10PLG | |
| SCHEMBL17381408 | 0.80 | F2 (0.53) | F2TMPRSS6TMPRSS11DF10PLG | |
| SCHEMBL8354790 | 0.79 | F2 (0.49) | F2TMPRSS6TMPRSS11DF10PLG | |
| SCHEMBL8345186 | 0.79 | F2 (0.51) | F2TMPRSS6TMPRSS11DF10PLG | |
| SCHEMBL12156653 | 0.79 | F2 (0.61) | F2TMPRSS6TMPRSS11DF10PLG | |
| SCHEMBL8346530 | 0.79 | F2 (0.57) | F2TMPRSS6TMPRSS11DF10PLG | |
| SCHEMBL13456455 | 0.77 | CYP2C9 (0.47) | F2F10PRSS1 | |
| SCHEMBL8291001 | 0.77 | F10 (0.56) | F2TMPRSS6TMPRSS11DF10PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483285-B1 | INHIBITORS OF THE BLOOD-CLOTTING FACTOR Xa, PRODUCTION THEREOF AND USE OF THE SAME | CURACYTE AG (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2003076457-A1 | INHIBITORS OF THE BLOOD-CLOTTING FACTOR Xa, PRODUCTION THEREOF AND USE OF THE SAME | CURACYTE AG (DE) | 2003-09-18 | — | — | WO | disclosed |