⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11299740 | 0.82 | ALDH1A1 (0.33) | — | |
| SCHEMBL2948335 | 0.69 | — | — | |
| SCHEMBL11820238 | 0.69 | — | — | |
| SCHEMBL3293884 | 0.67 | — | — | |
| SCHEMBL374360 | 0.67 | ALDH1A1 (0.30) | — | |
| SCHEMBL75613 | 0.67 | — | — | |
| SCHEMBL23064423 | 0.64 | — | — | |
| Hydrochloric Acid SCHEMBL9658417 | 0.64 | — | — | |
| Carbon Tetrachloride SCHEMBL11147171 | 0.64 | ALDH1A1 (0.40) | — | |
| Charcoal, Activated SCHEMBL12520682 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0046735-A2 | Process for the preparation of chloropyridines substituted with methyl or trifluoromethyl groups | CIBA-GEIGY AG (CH) | 1982-03-03 | — | — | EP | claimed |
| US-8497397-B2 | Substituted acrylamide derivative and pharmaceutical composition comprising the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-30 | — | — | US | disclosed |
| EP-1880720-B1 | SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAIICHI SANKYO CO LTD (JP) | 2013-02-13 | — | — | EP | disclosed |
| US-8344029-B2 | Substituted propanamide derivative and pharmaceutical composition containing the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-01-01 | — | — | US | disclosed |
| US-20120220593-A1 | Substituted Acrylamide Derivative and Pharmaceutical Composition Comprising the Same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-30 | — | — | US | disclosed |
| US-8143446-B2 | Substituted acrylamide derivative and pharmaceutical composition comprising the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-27 | — | — | US | disclosed |
| CN-101272774-B | Substituted acrylamide derivative and pharmaceutical composition comprising the same | DAIICHI SANKYO CO LTD | 2011-06-08 | — | — | CN | disclosed |
| US-20090292024-A1 | SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-11-26 | — | — | US | disclosed |
| US-20090118199-A1 | SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAIICHI SANKYO COMPANY , LIMITED (JP) | 2009-05-07 | — | — | US | disclosed |
| CN-101272774-A | Substituted acrylamide derivative and pharmaceutical composition comprising the same | DAIICHI SANKYO CO LTD (JP) | 2008-09-24 | — | — | CN | disclosed |
| EP-1908466-A1 | SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Daiichi Sankyo Company, Limited (JP) | 2008-04-09 | — | — | EP | disclosed |
| EP-1880720-A1 | SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Daiichi Sankyo Company, Limited (JP) | 2008-01-23 | — | — | EP | disclosed |
| EP-0137415-B1 | ADDITION OF POLYHALONITRILES TO FUNCTIONALIZED OLEFINS | THE DOW CHEMICAL COMPANY (US) | 1988-06-01 | — | — | EP | disclosed |
| EP-0113467-B1 | 2,2-DICHLORO-3,3,3-TRIFLUOROPROPION ALDEHYDE, AND PROCESS FOR ITS PREPARATION | CIBA-GEIGY AG (CH) | 1986-04-30 | — | — | EP | disclosed |
| EP-0137415-A2 | Addition of polyhalonitriles to functionalized olefins | THE DOW CHEMICAL COMPANY (US) | 1985-04-17 | — | — | EP | disclosed |
| US-4469896-A | Process for the production of chloropyridines substituted by methyl, trichloromethyl or trifluoromethyl groups | CIBA-GEIGY CORPORATION (US) | 1984-09-04 | — | — | US | disclosed |
| US-4469896-A | Process for the production of chloropyridines substituted by methyl, trichloromethyl or trifluoromethyl groups | CIBA-GEIGY CORPORATION (US) | 1984-09-04 | — | — | US | disclosed |
| EP-0113467-A2 | 2,2-Dichloro-3,3,3-trifluoropropion aldehyde, and process for its preparation | CIBA-GEIGY AG (CH) | 1984-07-18 | — | — | EP | disclosed |
| EP-0046735-A2 | Process for the preparation of chloropyridines substituted with methyl or trifluoromethyl groups | CIBA-GEIGY AG (CH) | 1982-03-03 | — | — | EP | disclosed |
| EP-0046735-A2 | Process for the preparation of chloropyridines substituted with methyl or trifluoromethyl groups | CIBA-GEIGY AG (CH) | 1982-03-03 | — | — | EP | disclosed |