Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.64 |
| ▸ | WNT3A | P56704 | 2/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.58 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.57 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | CLK1 | P49759 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348837 | 0.96 | PDPK1 (0.68) | PDPK1DYRK1AWNT3ALRRK2CSNK1D | |
| SCHEMBL30522062 | 0.96 | PDPK1 (0.68) | PDPK1DYRK1AWNT3ALRRK2CSNK1D | |
| SCHEMBL2684071 | 0.85 | DYRK1A (0.68) | PDPK1DYRK1AWNT3ALRRK2CSNK1D | |
| SCHEMBL17776540 | 0.83 | PDPK1 (0.72) | PDPK1DYRK1AWNT3ALRRK2CSNK1D | |
| SCHEMBL7933342 | 0.83 | PDPK1 (0.68) | PDPK1DYRK1AWNT3ALRRK2CSNK1D | |
| SCHEMBL17251987 | 0.83 | PDPK1 (0.68) | PDPK1DYRK1AWNT3ALRRK2CSNK1D | |
| SCHEMBL10936004 | 0.82 | DYRK1A (0.75) | PDPK1DYRK1AWNT3ALRRK2CSNK1D | |
| SCHEMBL8350055 | 0.81 | CASP2 (0.72) | DYRK1ACSNK1DNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30522064 | 0.81 | DYRK1A (0.68) | DYRK1ANPC1RAB9ASMN1; SMN2CYP2C9 | |
| SCHEMBL29095932 | 0.81 | DYRK1A (0.68) | DYRK1ANPC1RAB9ASMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |