Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.68 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.67 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.63 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ACP1 | P24666 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30522064 | 1.00 | DYRK1A (0.68) | DYRK1ADYRK2HSD17B1HSD17B2DYRK1B | |
| SCHEMBL30522062 | 0.84 | PDPK1 (0.68) | DYRK1ACYP2C9CYP2C19RAB9ANPC1 | |
| SCHEMBL29500269 | 0.84 | RAB9A (0.72) | DYRK1AHSD17B10RAB9ANPC1TP53 | |
| SCHEMBL8348837 | 0.84 | PDPK1 (0.68) | DYRK1ACYP2C9CYP2C19RAB9ANPC1 | |
| SCHEMBL28384921 | 0.84 | RAB9A (0.72) | DYRK1AHSD17B10RAB9ANPC1TP53 | |
| SCHEMBL544349 | 0.82 | DYRK1A (0.75) | DYRK1ADYRK2HSD17B1HSD17B2DYRK1B | |
| SCHEMBL29095959 | 0.81 | CSNK1D (0.74) | DYRK1ACYP2D6ACP1 | |
| SCHEMBL8354539 | 0.81 | PDPK1 (0.64) | DYRK1ACYP2C9CYP2C19RAB9ANPC1 | |
| SCHEMBL30522065 | 0.81 | CSNK1D (0.74) | DYRK1ACYP2D6ACP1 | |
| SCHEMBL29500248 | 0.81 | CASP2 (0.77) | DYRK1ACYP3A4CYP2C19RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116535366-B | Thiazole compound and preparation method and application thereof | 广州医科大学 | 2023-12-05 | — | — | CN | disclosed |
| CN-116535366-A | Thiazole compound and preparation method and application thereof | 广州医科大学 | 2023-08-04 | — | — | CN | disclosed |