Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 3/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 9/20 | 0.43 |
| ▸ | CASP6 | P55212 | 5/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 5/20 | 0.43 |
| ▸ | CASP1 | P29466 | 4/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CASP9 | P55211 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209157 | 0.89 | ANPEP (0.48) | PSMB8PSMB5CASP3CASP6CASP8 | |
| SCHEMBL7209163 | 0.89 | ANPEP (0.48) | PSMB8PSMB5CASP3CASP6CASP8 | |
| SCHEMBL6607398 | 0.79 | CASP1 (0.56) | CASP3CASP6CASP8CASP1 | |
| SCHEMBL8353758 | 0.78 | CASP3 (0.46) | PSMB5CASP3CASP6CASP8CASP1 | |
| SCHEMBL6832897 | 0.75 | CASP3 (0.61) | CASP3CASP6CASP8CASP1CASP7 | |
| SCHEMBL6832898 | 0.75 | CASP3 (0.61) | CASP3CASP6CASP8CASP1CASP7 | |
| SCHEMBL14598394 | 0.73 | CASP3 (0.56) | CASP3CASP6CASP8CASP1CASP7 | |
| SCHEMBL3588243 | 0.72 | CASP1 (0.56) | CASP3CASP6CASP8CASP1CASP7 | |
| SCHEMBL3588248 | 0.72 | CASP1 (0.56) | CASP3CASP6CASP8CASP1CASP7 | |
| SCHEMBL9632016 | 0.71 | HRH4 (0.47) | CTNNB1MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003072528-A2 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | IDUN PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |