Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.33 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 3/20 | 0.32 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | CA9 | Q16790 | 3/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3468702 | 0.76 | CA12 (0.44) | KMT2AMEN1ALDH1A1ABCC9ABCC8 | |
| SCHEMBL1477073 | 0.75 | ESR1 (0.34) | KMT2AALDH1A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL2303282 | 0.75 | TSHR (0.44) | KMT2AMEN1ALDH1A1ATRCYP3A4 | |
| SCHEMBL18148609 | 0.75 | F2 (0.42) | ATRHSD11B1CA1CA2CA9 | |
| SCHEMBL883462 | 0.75 | TSHR (0.44) | KMT2AMEN1ALDH1A1ATRCYP3A4 | |
| SCHEMBL22578640 | 0.73 | ALDH1A1 (0.41) | KMT2AALDH1A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL12750939 | 0.72 | CA1 (0.43) | KMT2AMEN1ALDH1A1ABCC9ABCC8 | |
| SCHEMBL837152 | 0.72 | HTT (0.40) | ALDH1A1TSHRMAPT | |
| SCHEMBL23145884 | 0.71 | ATR (0.40) | KMT2AMEN1ALDH1A1ATRCA1 | |
| SCHEMBL10051833 | 0.71 | HSD11B1 (0.50) | KMT2AMEN1ALDH1A1CYP3A4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143410-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110263611-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2011-10-27 | — | — | US | disclosed |
| US-7915443-B2 | Sulfoximines as kinase inhibitors | ALLERGAN, INC. (US) | 2011-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263611-A1 | Kinase Inhibitors | PTK2, MAP3K6, MAP3K20 | KMT2A 1670/4885MEN1 3831/4885ALDH1A1 2605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.