SCHEMBL8354934

SCHEMBL8354934

CC(=O)O[C@H]1CC(n2c3ccccc3c3c4c(c5c6ccccc6[nH]c5c32)C(=O)NC4=O)[C@H](O)[C@@H]1O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 5/20 0.59
PRKCQ Q04759 9/20 0.59
CDK4 P11802 6/20 0.54
CCND1 P24385 6/20 0.54
PRKCA P17252 6/20 0.52
PRKD3 O94806 4/20 0.52
PRKCG P05129 4/20 0.52
PRKCB P05771 4/20 0.52
PRKCH P24723 4/20 0.52
PRKCI P41743 4/20 0.52
PRKCE Q02156 4/20 0.52
PRKCZ Q05513 4/20 0.52
PRKCD Q05655 4/20 0.52
PRKD1 Q15139 4/20 0.52
CCNE2 O96020 4/20 0.49
CCNE1 P24864 4/20 0.49
CDK2 P24941 4/20 0.49
PRKACA P17612 3/20 0.49
PRKACG P22612 3/20 0.49
PRKACB P22694 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8353659 0.92 ROCK2 (0.57) ROCK2PRKCQCDK4CCND1PRKCA
SCHEMBL8354275 0.92 ROCK2 (0.57) ROCK2PRKCQCDK4CCND1PRKCA
SCHEMBL8354092 0.90 PRKCA (0.50) ROCK2PRKCQCDK4CCND1PRKCA
SCHEMBL8354820 0.87 ROCK2 (0.53) ROCK2PRKCQCDK4CCND1PRKCA
SCHEMBL8352405 0.86 PRKCQ (0.63) ROCK2PRKCQCDK4CCND1PRKCA
SCHEMBL8350893 0.86 PRKCQ (0.63) ROCK2PRKCQCDK4CCND1PRKCA
SCHEMBL8352230 0.85 PRKCQ (0.62) ROCK2PRKCQCDK4CCND1PRKCA
SCHEMBL14440392 0.85 PRKCQ (0.62) ROCK2PRKCQCDK4CCND1PRKCA
SCHEMBL14440424 0.84 PRKCQ (0.58) ROCK2PRKCQCDK4CCND1PRKCA
SCHEMBL8354798 0.82 ROCK2 (0.55) ROCK2PRKCQCDK4CCND1PRKCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7262215-B2 N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors NAD AG (DE) 2007-08-28 US disclosed
US-7262215-B2 N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors NAD AG (DE) 2007-08-28 US disclosed
WO-2003051887-A1 N-CARBACYCLE MONOSUBSTITUTED INDOLOCARBAZOLES AS PROTEIN KINASE INHIBITORS NAD AG (DE) 2003-06-26 WO disclosed