Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.64 |
| ▸ | KDM1A | O60341 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KMO | O15229 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | VCP | P55072 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673316 | 0.86 | KDM1A (0.80) | MEN1KMT2ACSNK2A1KDM1AMAPT | |
| SCHEMBL2762558 | 0.85 | MEN1 (0.77) | MEN1KMT2ACSNK2A1KDM1AMAPT | |
| SCHEMBL8359224 | 0.85 | MEN1 (0.64) | MEN1KMT2ACSNK2A1KDM1AMAPT | |
| SCHEMBL5966304 | 0.82 | KDM1A (0.66) | MEN1KMT2ACSNK2A1KDM1AMAPT | |
| SCHEMBL27182617 | 0.82 | KDM1A (0.68) | MEN1KMT2ACSNK2A1KDM1AMAPT | |
| SCHEMBL6435702 | 0.80 | KDM1A (0.66) | MEN1KMT2ACSNK2A1KDM1AMAPT | |
| SCHEMBL2762482 | 0.80 | KDM1A (0.68) | MEN1KMT2AKDM1AMAPTPOLB | |
| SCHEMBL8355083 | 0.80 | KDM1A (0.84) | MEN1KMT2AKDM1APOLBKMO | |
| SCHEMBL728110 | 0.80 | KDM1A (0.74) | MEN1KMT2AKDM1AMAPTPOLB | |
| SCHEMBL727088 | 0.80 | KDM1A (0.74) | MEN1KMT2ACSNK2A1KDM1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958910-A | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5877193-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0819681-A2 | N-(4-Aryl-thiazol-2-yl)-sulfonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-21 | — | — | EP | disclosed |