Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835548 | 1.00 | AKR1C3 (0.58) | AKR1C3TRPM8DHODHHTTALDH1A1 | |
| SCHEMBL1629856 | 0.83 | AKR1C3 (0.64) | AKR1C3TRPM8DHODHHTTALDH1A1 | |
| SCHEMBL2638459 | 0.76 | AKR1C3 (0.66) | AKR1C3TRPM8DHODHHTTALDH1A1 | |
| SCHEMBL7886211 | 0.76 | NPSR1 (0.52) | HTTALDH1A1TSHRRAB9ANPC1 | |
| SCHEMBL759656 | 0.74 | AKR1C3 (0.75) | AKR1C3TRPM8DHODHHTTALDH1A1 | |
| SCHEMBL805622 | 0.74 | AKR1C3 (0.75) | AKR1C3TRPM8DHODHHTTALDH1A1 | |
| SCHEMBL41906 | 0.74 | AKR1C3 (1.00) | AKR1C3TRPM8DHODHHTTALDH1A1 | |
| SCHEMBL759655 | 0.74 | AKR1C3 (0.75) | AKR1C3TRPM8DHODHHTTALDH1A1 | |
| SCHEMBL2532810 | 0.74 | AKR1C3 (0.75) | AKR1C3TRPM8DHODHHTTALDH1A1 | |
| SCHEMBL37034 | 0.74 | AKR1C3 (1.00) | AKR1C3TRPM8DHODHHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143423-B2 | N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-03-27 | — | — | US | disclosed |
| US-20100105921-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105921-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | NDC1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HAO2 | AKR1C3 652/4885TRPM8 4490/4885DHODH 228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.