Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | CASP1 | P29466 | 2/20 | 0.60 |
| ▸ | CASP7 | P55210 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20856880 | 0.87 | TSHR (0.51) | ALDH1A1HSD17B10MAPTMEN1KMT2A | |
| Lactic Acid SCHEMBL11226196 | 0.84 | HSD17B10 (0.68) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| Ethacridine SCHEMBL30775016 | 0.75 | MEN1 (1.00) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| Ethacridine SCHEMBL138154 | 0.75 | MEN1 (1.00) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| Ethacridine SCHEMBL31197660 | 0.75 | MEN1 (1.00) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| Ethacridine SCHEMBL30006678 | 0.75 | MEN1 (1.00) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| Lactic Acid SCHEMBL8375854 | 0.75 | MEN1 (0.91) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| Ethacridine SCHEMBL8676831 | 0.74 | MEN1 (0.98) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| Ethacridine SCHEMBL29355684 | 0.74 | MEN1 (0.98) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| Ethacridine SCHEMBL1649444 | 0.74 | MEN1 (0.98) | ALDH1A1HSD17B10MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919708-A | SEPARATING GLYCATED HEMOGLOBIN FROM NONGLYCATED PROTEINS USING PRECIPITATING AGENT, BINDING CHROMOPHORE LABELED BORONIC ACID/SALT TO GLYCATED HEMOGLOBIN, OPTIONALLY ADDING NONSPECIFICALLY BINDING SIGNAL AGENT, ASSESSING SIGNALS | AXIS BIOCHEMICALS AS (NO) | 1999-07-06 | — | — | US | disclosed |
| US-5506144-A | SEPARATING NON-GLYCATED PROTEINS BY PRECIPITATION, CONTRACTING WITH SIGNAL FORMING AGENT SPECIFIC FOR GLYCATED PROTEIN | AXIS BIOCHEMICALS AS (NO) | 1996-04-09 | — | — | US | disclosed |
| EP-0557350-B1 | ASSAY FOR GLYCATED BLOOD PROTEINS | AXIS BIOCHEMICALS AS (NO) | 1994-10-05 | — | — | EP | disclosed |
| EP-0557350-A1 | ASSAY FOR GLYCATED BLOOD PROTEINS. | AXIS RESEARCH (NO) | 1993-09-01 | — | — | EP | disclosed |
| WO-1992008984-A1 | ASSAY FOR GLYCATED BLOOD PROTEINS | AXIS RESEARCH AS (NO) | 1992-05-29 | — | — | WO | disclosed |