Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TERT | O14746 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL8355582 | 0.87 | ALDH1A1 (0.60) | TSHRALDH1A1TP53CYP3A4HSD17B10 | |
| SCHEMBL20856778 | 0.79 | KMT2A (0.59) | TSHRALDH1A1TP53CYP3A4HSD17B10 | |
| Water SCHEMBL30558837 | 0.79 | TLR8 (0.51) | TSHRALDH1A1TP53CYP3A4HSD17B10 | |
| SCHEMBL5952240 | 0.73 | MEN1 (0.66) | TSHRALDH1A1TP53CYP3A4HSD17B10 | |
| SCHEMBL30646246 | 0.73 | MEN1 (0.66) | TSHRALDH1A1TP53CYP3A4HSD17B10 | |
| SCHEMBL23458226 | 0.72 | NQO1 (0.62) | TSHRALDH1A1TP53CYP3A4HSD17B10 | |
| SCHEMBL29629327 | 0.72 | NQO1 (0.68) | TSHRALDH1A1TP53CYP3A4HSD17B10 | |
| SCHEMBL3825385 | 0.72 | NQO1 (0.68) | TSHRALDH1A1TP53CYP3A4HSD17B10 | |
| SCHEMBL9694076 | 0.71 | KDM4E (0.54) | TSHRALDH1A1TP53CYP3A4HSD17B10 | |
| SCHEMBL23452966 | 0.71 | NCF1 (0.74) | TSHRALDH1A1TP53CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12247246-B2 | Identification of inhibitors of TcpC and TIR NADase activity | WASHINGTON UNIVERSITY (US) | 2025-03-11 | — | — | US | disclosed |
| US-20230272449-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | WASHINGTON UNIVERSITY | 2023-08-31 | — | — | US | disclosed |
| US-20200283820-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | WASHINGTON UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| WO-2019067625-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADASE ACTIVITY | WASHINGTON UNIVERSITY (US) | 2019-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230272449-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | NADK, NAPRT, TIPARP | TSHR 2861/4885ALDH1A1 2853/4885TP53 1377/4885 |
| US-12247246-B2 | Identification of inhibitors of TcpC and TIR NADase activity | NADK, NAPRT, TIPARP | TSHR 2861/4885ALDH1A1 2853/4885TP53 1377/4885 |
| US-20200283820-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | NADK, NAPRT, TIPARP | TSHR 2861/4885ALDH1A1 2853/4885TP53 1377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.