Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | LIPE | Q05469 | 3/20 | 0.36 |
| ▸ | PTGIR | P43119 | 2/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28374447 | 0.77 | HSD17B10 (0.50) | HTTHSD17B10L3MBTL1TAS2R14ALDH1A1 | |
| SCHEMBL8362229 | 0.75 | RXRA (0.49) | HTTHSD17B10 | |
| SCHEMBL8358184 | 0.71 | HTT (0.43) | HTTHSD17B10TAS2R14ALDH1A1KMO | |
| SCHEMBL16965604 | 0.70 | L3MBTL1 (0.70) | HTTL3MBTL1ATMTDP1LMNA | |
| SCHEMBL6730105 | 0.70 | KDM4E (0.43) | HTTL3MBTL1ATMTDP1LMNA | |
| SCHEMBL8362451 | 0.68 | HTT (0.51) | HTTHSD17B10L3MBTL1TAS2R14ALDH1A1 | |
| SCHEMBL11964238 | 0.68 | HTT (0.51) | HTTHSD17B10L3MBTL1TAS2R14ALDH1A1 | |
| SCHEMBL8356321 | 0.68 | ATM (0.42) | L3MBTL1ATMTDP1LMNANPSR1 | |
| SCHEMBL17092998 | 0.67 | L3MBTL1 (0.66) | HTTL3MBTL1ATMTDP1LMNA | |
| SCHEMBL17329609 | 0.67 | HTT (0.41) | HTTHSD17B10L3MBTL1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999041237-A1 | SUBSTITUTED PYRIDINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | G.D. SEARLE & CO. (US) | 1999-08-19 | — | — | WO | disclosed |