Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2872397 | 0.83 | POLB (0.58) | POLBSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL2872394 | 0.83 | POLB (0.58) | POLBSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL1970389 | 0.81 | POLB (0.56) | POLBSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL12649504 | 0.81 | POLB (0.60) | POLBSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL11148031 | 0.79 | POLB (0.66) | POLBSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL19116647 | 0.77 | LMNA (0.62) | POLBSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL6381037 | 0.77 | POLB (0.52) | POLBSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL15309318 | 0.77 | LMNA (0.55) | POLBSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL9931372 | 0.76 | POLB (0.55) | POLBSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL14520163 | 0.76 | POLB (0.62) | POLBSMN1; SMN2KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |