Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19360672 | 0.85 | POLB (0.74) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL21325740 | 0.79 | POLB (0.74) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL8356392 | 0.76 | POLB (0.56) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL1970389 | 0.76 | POLB (0.56) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL2872394 | 0.74 | POLB (0.58) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL12649504 | 0.73 | POLB (0.60) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL20828337 | 0.71 | POLB (0.55) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL11148031 | 0.70 | POLB (0.66) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL19116647 | 0.69 | LMNA (0.62) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL6381037 | 0.69 | POLB (0.52) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070082918-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS AND COMPOUNDS WITH MULTIPLE ACTIVITIES | NAFTCHI N E | 2007-04-12 | — | — | US | disclosed |
| US-20070082918-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS AND COMPOUNDS WITH MULTIPLE ACTIVITIES | NAFTCHI N E | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082918-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS AND COMPOUNDS WITH MULTIPLE ACTIVITIES | ADRB2, ADRB1, CHRNA7 | POLB 2849/4885SMN1; SMN2 150/4885ESR2 918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.