Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.65 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.56 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8356932 | 0.90 | LMNA (0.73) | LMNAALDH1A1PLA2G2AMTNR1AMTNR1B | |
| SCHEMBL8358799 | 0.86 | NR4A2 (0.53) | LMNAALDH1A1PLA2G2ASERPINE1NR4A2 | |
| SCHEMBL28853763 | 0.86 | LMNA (0.71) | LMNAALDH1A1PLA2G2AMTNR1AMTNR1B | |
| SCHEMBL2430574 | 0.84 | NR4A2 (0.72) | LMNAALDH1A1CNR1CNR2NR4A2 | |
| SCHEMBL28511884 | 0.83 | LMNA (0.61) | LMNAALDH1A1PLA2G2AMTNR1AMTNR1B | |
| SCHEMBL28508117 | 0.82 | LMNA (0.62) | LMNAALDH1A1PLA2G2AMTNR1AMTNR1B | |
| SCHEMBL1548669 | 0.81 | LMNA (0.94) | LMNAALDH1A1CHRM1 | |
| SCHEMBL20769739 | 0.81 | PLA2G2A (0.83) | LMNAALDH1A1PLA2G2AMTNR1AMTNR1B | |
| SCHEMBL28512821 | 0.80 | LMNA (0.57) | LMNAALDH1A1PLA2G2AMTNR1AMTNR1B | |
| SCHEMBL5066775 | 0.80 | NR4A2 (0.51) | LMNAALDH1A1PLA2G2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | disclosed |
| EP-0746544-B1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMA INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0746544-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995022524-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-24 | — | — | WO | disclosed |