Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.71 |
| ▸ | MMP10 | P09238 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479481 | 0.94 | MMP13 (0.71) | MMP13MMP10MMP9MMP8PTGER4 | |
| SCHEMBL14256100 | 0.91 | MMP13 (0.65) | MMP13MMP10MMP9MMP8HDAC3 | |
| SCHEMBL14448540 | 0.91 | MMP13 (0.65) | MMP13MMP10MMP9MMP8PTGER4 | |
| SCHEMBL8357422 | 0.91 | MMP13 (0.61) | MMP13MMP10MMP9MMP8HDAC3 | |
| SCHEMBL8357432 | 0.90 | MMP13 (0.67) | MMP13MMP10MMP9MMP8HDAC3 | |
| SCHEMBL8349489 | 0.89 | MMP13 (0.62) | MMP13MMP10MMP9MMP8HDAC3 | |
| SCHEMBL8348824 | 0.88 | NPC1 (0.58) | MMP13PPARGALDH1A1SMN1; SMN2ANO1 | |
| SCHEMBL8348424 | 0.87 | MMP13 (0.60) | MMP13MMP10MMP9MMP8HDAC3 | |
| SCHEMBL8360230 | 0.87 | MEN1 (0.58) | MMP13 | |
| SCHEMBL8360133 | 0.86 | MMP13 (0.62) | MMP13MMP10MMP9MMP8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455790-B1 | USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-03-26 | — | — | EP | disclosed |
| WO-2003049738-A1 | USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-06-19 | — | — | WO | disclosed |