SCHEMBL8357978

SCHEMBL8357978

CNC(=O)C(=NOC)c1cc(CON=CCc2cccc(C(F)(F)F)c2)ccc1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.38
FFAR4 Q5NUL3 2/20 0.38
MAPT P10636 2/20 0.36
HTT P42858 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MAOB P27338 4/20 0.36
IDO1 P14902 2/20 0.35
KDM4E B2RXH2 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
THRB P10828 1/20 0.35
F2 P00734 1/20 0.35
FFAR1 O14842 1/20 0.35
ALDH1A1 P00352 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NR4A2 P43354 2/20 0.34
PRKCA P17252 1/20 0.34
PRKCD Q05655 1/20 0.34
CARM1 Q86X55 1/20 0.34
PRMT6 Q96LA8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2890313 0.86 HIF1A (0.51) HIF1AMAPTHTTL3MBTL1MAOB
SCHEMBL2890312 0.86 HIF1A (0.51) HIF1AMAPTHTTL3MBTL1MAOB
SCHEMBL8357976 0.82 PPARG (0.44) HIF1AMAPTMAOBMEN1KMT2A
SCHEMBL8760920 0.80 HIF1A (0.44) HIF1AMAPTHTTL3MBTL1MAOB
SCHEMBL8423691 0.77 HIF1A (0.61) HIF1AMAPTHTTL3MBTL1MAOB
SCHEMBL27038477 0.77 HIF1A (0.61) HIF1AMAPTHTTL3MBTL1MAOB
SCHEMBL8760916 0.75 HIF1A (0.46) HIF1AMAPTHTTL3MBTL1MAOB
SCHEMBL24217491 0.74 RECQL (0.41) HIF1AMAPTHTTL3MBTL1MAOB
SCHEMBL9023766 0.73 HIF1A (0.47) HIF1AMAPTHTTL3MBTL1MAOB
SCHEMBL8355862 0.72 HIF1A (0.42) HIF1AMAOBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999028305-A1 FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-06-10 WO claimed
WO-1999028305-A1 FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-06-10 WO disclosed