SCHEMBL8760920

SCHEMBL8760920

CNC(=O)C(=NOC)c1ccccc1C=NOCc1cccc(C(F)(F)F)c1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 4/20 0.44
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
MAPT P10636 3/20 0.38
HTT P42858 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MAOB P27338 2/20 0.38
LMNA P02545 1/20 0.37
ADCYAP1R1 P41586 1/20 0.37
KMT2A Q03164 2/20 0.37
POLB P06746 1/20 0.37
NR4A2 P43354 1/20 0.36
PRKCA P17252 1/20 0.36
PRKCD Q05655 1/20 0.36
MEN1 O00255 1/20 0.36
SPHK2 Q9NRA0 1/20 0.36
SPHK1 Q9NYA1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL154410 0.91 HIF1A (0.41) HIF1AKDM4EALDH1A1SMN1; SMN2MAPT
SCHEMBL321895 0.91 HIF1A (0.41) HIF1AKDM4EALDH1A1SMN1; SMN2MAPT
SCHEMBL15650134 0.91 HIF1A (0.41) HIF1AKDM4EALDH1A1SMN1; SMN2MAPT
SCHEMBL8760949 0.91 HIF1A (0.54) HIF1AKDM4EMAPTHTTL3MBTL1
SCHEMBL8760953 0.91 HIF1A (0.54) HIF1AKDM4EMAPTHTTL3MBTL1
SCHEMBL8761034 0.87 HDAC3 (0.41) HIF1AKDM4EALDH1A1MAPTMAOB
SCHEMBL2890312 0.82 HIF1A (0.51) HIF1AKDM4EALDH1A1SMN1; SMN2MAPT
SCHEMBL2890313 0.82 HIF1A (0.51) HIF1AKDM4EALDH1A1SMN1; SMN2MAPT
SCHEMBL154409 0.81 HIF1A (0.36) HIF1AKDM4ESMN1; SMN2MAPTHTT
SCHEMBL8461974 0.81 HIF1A (0.36) HIF1AKDM4ESMN1; SMN2MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-7076564-A None JP disclosed
EP-0596254-B1 Methoxyiminoacetic acid derivative and agricultural/horticultural fungicide containing the same as active ingredient MITSUBISHI CHEM CORP (JP) 1997-06-04 EP disclosed
US-5407902-A Methoxyiminoacetic acid derivative and agricultural/horticultural fungicide containing the same as active ingredient MITSUBISHI KASEI CORPORATION (JP) 1995-04-18 US disclosed
JP-H0776564-A METHOXYIMINO ACETIC ACID DERIVATIVE AND AGRICULTURAL OR HORTICULTURAL ANTIMICROBIAL AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT MITSUBISHI CHEM CORP 1995-03-20 JP disclosed
EP-0596254-A1 Methoxyiminoacetic acid derivative and agricultural/horticultural fungicide containing the same as active ingredient Mitsubishi Chemical Corporation (JP) 1994-05-11 EP disclosed