SCHEMBL8358402

SCHEMBL8358402

COC(=O)COc1cccc(CCCn2cc(C(c3ccccc3)c3ccccc3)cn2)c1

nearest known ligand 0.55

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 12/20 0.55
PTGDR Q13258 1/20 0.47
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
PTGIR P43119 2/20 0.46
PPARG P37231 2/20 0.43
PPARA Q07869 2/20 0.43
FAAH O00519 1/20 0.41
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8804127 0.90 PTGDR2 (0.67) PTGDR2PTGDRPTGIRPPARGPPARA
SCHEMBL8965375 0.87 PTGDR2 (0.63) PTGDR2PTGDRPTGIRPPARGPPARA
SCHEMBL8965139 0.84 PTGDR2 (0.61) PTGDR2PTGDRPTGIRPPARGPPARA
SCHEMBL8354768 0.83 PTGDR2 (0.53) PTGDR2PTGDRPTGIR
SCHEMBL8965728 0.82 PTGDR2 (0.57) PTGDR2PTGDRPTGIRPPARGPPARA
SCHEMBL12678767 0.82 PTGDR2 (0.82) PTGDR2PTGDRMEN1KMT2APTGIR
SCHEMBL8965896 0.79 PTGIR (0.53) PTGDR2PTGIRPPARA
SCHEMBL8965035 0.78 PTGDR2 (0.55) PTGDR2PTGDRPTGIRPPARGPPARA
SCHEMBL8965077 0.78 PTGDR2 (0.61) PTGDR2PTGDRPTGIRPPARGPPARA
SCHEMBL8354769 0.78 PTGIR (0.55) PTGDR2KMT2APTGIR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5935985-A Phenoxyacetic acid derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 1999-08-10 US disclosed
US-5703099-A TREATMENT OF THROMBOSIS, ARTERIOSCLEROSIS, ISCHEMIC HEART DISEASES, GASTRIC ULCER OR HYPERTENSION ONO PHARMACEUTICAL CO., LTD. (JP) 1997-12-30 US disclosed
EP-0558062-B1 Phenoxyacetic acid derivatives and pharmaceutical compositions containing them ONO PHARMACEUTICAL CO (JP) 1997-05-07 EP disclosed
US-5536736-A CARDIOVASCULAR DISORDERS ONO PHARMACEUTICAL CO., LTD. (JP) 1996-07-16 US disclosed
US-5378716-A Prostaglandin agonists ONO PHARMACEUTICAL CO., LTD. (JP) 1995-01-03 US disclosed
EP-0558062-A2 Phenoxyacetic acid derivatives and pharmaceutical compositions containing them ONO PHARMACEUTICAL CO., LTD. (JP) 1993-09-01 EP disclosed