Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6392924 | 0.89 | KDM4E (0.49) | NR1H4KDM4ENAMPTMEN1KMT2A | |
| SCHEMBL6168711 | 0.76 | KMT2A (0.43) | HDAC1EPHX2NR1H4KDM4EMEN1 | |
| SCHEMBL6298067 | 0.73 | KDM4E (0.50) | HDAC1KDM4ENAMPTMEN1KMT2A | |
| SCHEMBL4015377 | 0.73 | P2RX1 (0.56) | MEN1KMT2ACYP2C19SMN1; SMN2CYP1A2 | |
| SCHEMBL19682558 | 0.72 | KMT2A (0.60) | HDAC1EPHX2NR1H4NAMPTMEN1 | |
| SCHEMBL6945571 | 0.72 | HTT (0.50) | EPHX2NR1H4NAMPTMEN1KMT2A | |
| SCHEMBL10165179 | 0.72 | NAMPT (0.56) | HDAC1EPHX2NR1H4NAMPTMEN1 | |
| SCHEMBL1560690 | 0.70 | CA1 (0.53) | — | |
| SCHEMBL4449295 | 0.70 | PTGER4 (0.50) | EPHX2NR1H4NAMPTMEN1KMT2A | |
| SCHEMBL7328964 | 0.69 | MAP2K1 (0.38) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003032999-A1 | ALKYNE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2003-04-24 | — | — | WO | disclosed |