Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | DGKA | P23743 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28697337 | 1.00 | LMNA (0.63) | LMNAMAPTMAPK1ALDH1A1DGKA | |
| SCHEMBL28120518 | 1.00 | LMNA (0.63) | LMNAMAPTMAPK1ALDH1A1DGKA | |
| SCHEMBL28120938 | 1.00 | LMNA (0.63) | LMNAMAPTMAPK1ALDH1A1DGKA | |
| SCHEMBL28931646 | 1.00 | LMNA (0.63) | LMNAMAPTMAPK1ALDH1A1DGKA | |
| SCHEMBL6898365 | 1.00 | LMNA (0.63) | LMNAMAPTMAPK1ALDH1A1DGKA | |
| SCHEMBL28120517 | 1.00 | LMNA (0.63) | LMNAMAPTMAPK1ALDH1A1DGKA | |
| SCHEMBL8062967 | 0.98 | LMNA (0.60) | LMNAMAPTMAPK1ALDH1A1DGKA | |
| SCHEMBL67893 | 0.84 | ALDH1A1 (0.48) | LMNAMAPTMAPK1ALDH1A1CES2 | |
| SCHEMBL706084 | 0.82 | LMNA (0.71) | LMNAMAPTMAPK1ALDH1A1DGKA | |
| SCHEMBL12019085 | 0.80 | LMNA (0.58) | LMNAMAPTMAPK1ALDH1A1DGKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9895379-B2 | 17alpha, 21-dihydroxypregnene esters as antiandrogenic agents | CASSIOPEA S.P.A. (IT) | 2018-02-20 | — | — | US | disclosed |
| US-20160263127-A1 | 17 Alpha, 21-Dihydroxypregnene Esters as Antiandrogenic Agents | COSMO DERMATOS SRL. (IT) | 2016-09-15 | — | — | US | disclosed |
| US-9211295-B2 | 17 alpha, 21-dihydroxypregnene esters as antiandrogenic agents | CASSIOPEA S.P.A. (IT) | 2015-12-15 | — | — | US | disclosed |
| US-20150216878-A1 | 17 Alpha, 21-Dihydroxypregnene Esters as Antiandrogenic Agents | CASSIOPEA S.P.A. (IT) | 2015-08-06 | — | — | US | disclosed |
| US-8865690-B2 | 17alfa, 21-dihydroxypregnene esters as antiandrogenic agents | COSMO DERMATOS SRL (IT) | 2014-10-21 | — | — | US | disclosed |
| US-20140154306-A1 | 17ALFA, 21-DIHYDROXYPREGNENE ESTERS AS ANTIANDROGENIC AGENTS | COSMO S.P.A. (IT) | 2014-06-05 | — | — | US | disclosed |
| CN-102383306-B | Fluorine-containing modified vegetable oil polymer water-repellent finishing agent, and preparation and application thereof | UNIV DONGHUA | 2014-01-08 | — | — | CN | disclosed |
| US-20120149671-A1 | 17ALPHA, 21-DIHYDROXYPREGNENE ESTERS AS ANTIANDROGENIC AGENTS | COSMO SPA, (IT) | 2012-06-14 | — | — | US | disclosed |
| US-8143240-B2 | 17α, 21-dihydroxypregnene esters as antiandrogenic agents | COSMO S.P.A. (IT) | 2012-03-27 | — | — | US | disclosed |
| CN-102383306-A | Fluorine-containing modified vegetable oil polymer water-repellent finishing agent, and preparation and application thereof | UNIV DONGHUA | 2012-03-21 | — | — | CN | disclosed |
| CN-101608402-B | Vegetable oil modified fluoride-containing water repellent finishing agent as well as preparation method and application thereof | UNIV DONGHUA | 2011-07-27 | — | — | CN | disclosed |
| CN-101608402-A | Vegetable oil modified fluoride-containing water repellent finishing agent, preparation method and application thereof | UNIV DONGHUA (CN) | 2009-12-23 | — | — | CN | disclosed |
| US-20090264396-A1 | 17Alpha, 21-Dihydroxypregnene esters as antiandrogenic agents | COSMO SPA (IT) | 2009-10-22 | — | — | US | disclosed |
| CN-1246328-C | 17 alfa, 21-dihydroxypregnene esters as antiandrogenic agents | COSMO SPA (IT) | 2006-03-22 | — | — | CN | disclosed |
| EP-1421099-B1 | 17ALFA, 21-DIHYDROXYPREGNENE ESTERS AS ANTIANDROGENIC AGENTS | COSMO SPA (IT) | 2005-02-16 | — | — | EP | disclosed |
| US-20050026889-A1 | Treating acne, seborrhea, hirsutism, alopecia, mastodynia, prostate hyperplasia and carcinoma, virilization syndromes in the female, early puberty, use in inhibition of sexual aggressiveness in the male, male contraception | COSMO SPA. (IT) | 2005-02-03 | — | — | US | disclosed |
| CN-1541220-A | 17 alpha, 21-dihydroxypregnene esters as antiandrogens | �������˹��ĭ�ۺ���ɷ�����˾ | 2004-10-27 | — | — | CN | disclosed |
| EP-1421099-A1 | 17ALFA, 21-DIHYDROXYPREGNENE ESTERS AS ANTIANDROGENIC AGENTS | Cosmo S.p.A. (IT) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003014141-A1 | 17ALFA, 21-DIHYDROXYPREGNENE ESTERS AS ANTIANDROGENIC AGENTS | COSMO S.P.A. (IT) | 2003-02-20 | — | — | WO | disclosed |
| WO-1994019309-A1 | A NOVEL METHOD FOR THE PREPARATION OF OPTICALLY ACTIVE COMPOUNDS AS WELL AS NOVEL END PRODUCTS | MAEENSIVU EIJA (FI) | 1994-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160263127-A1 | 17 Alpha, 21-Dihydroxypregnene Esters as Antiandrogenic Agents | HSD17B11, CYP17A1, NR5A1 | LMNA 862/4885MAPT 4721/4885MAPK1 2171/4885 |
| US-20050026889-A1 | Treating acne, seborrhea, hirsutism, alopecia, mastodynia, prostate hyperplasia and carcinoma, virilization syndromes in the female, early puberty, use in inhibition of sexual aggressiveness in the male, male contraception | CYP17A1, CYP19A1, HSD17B3 | LMNA 2052/4885MAPT 3186/4885MAPK1 2321/4885 |
| US-20140154306-A1 | 17ALFA, 21-DIHYDROXYPREGNENE ESTERS AS ANTIANDROGENIC AGENTS | NR5A1, CYP17A1, HSD17B11 | LMNA 935/4885MAPT 4392/4885MAPK1 1423/4885 |
| US-20090264396-A1 | 17Alpha, 21-Dihydroxypregnene esters as antiandrogenic agents | HSD17B11, NR5A1, CYP17A1 | LMNA 1518/4885MAPT 4630/4885MAPK1 1029/4885 |
| US-20150216878-A1 | 17 Alpha, 21-Dihydroxypregnene Esters as Antiandrogenic Agents | HSD17B11, CYP17A1, NR5A1 | LMNA 1373/4885MAPT 4625/4885MAPK1 1136/4885 |
| US-20120149671-A1 | 17ALPHA, 21-DIHYDROXYPREGNENE ESTERS AS ANTIANDROGENIC AGENTS | HSD17B11, NR5A1, CYP17A1 | LMNA 1485/4885MAPT 4620/4885MAPK1 1030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.