SCHEMBL8358974

SCHEMBL8358974

Cc1cnc2nc(NS(=O)(=O)c3ccccc3Cl)nn2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.50
LMNA P02545 1/20 0.46
EDNRA P25101 2/20 0.44
EDNRB P24530 1/20 0.43
CCR4 P51679 1/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
SLC40A1 Q9NP59 2/20 0.41
PKM P14618 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.41
HTT P42858 1/20 0.40
BRD4 O60885 1/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
HSD17B10 Q99714 1/20 0.39
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8358849 0.88 GAA (0.46) GAALMNAEDNRACCR4MEN1
SCHEMBL8357447 0.80 SLC40A1 (0.49) GAALMNAEDNRAEDNRBCCR4
SCHEMBL8355169 0.76 GAA (0.52) GAALMNAEDNRAEDNRBCCR4
SCHEMBL9830515 0.76 SLC40A1 (0.35) GAACCR4KMT2ASLC40A1TSHR
SCHEMBL10732824 0.75 GAA (0.50) GAALMNAEDNRAEDNRBCCR4
SCHEMBL8358795 0.74 SLC40A1 (0.36) KMT2ASLC40A1ALDH1A1TSHR
SCHEMBL8356736 0.72 SLC40A1 (0.36) CCR4SLC40A1ALDH1A1
SCHEMBL9832309 0.72 CCR4 (0.34) EDNRAEDNRBCCR4SLC40A1HTT
SCHEMBL9831943 0.72 SLC40A1 (0.33) GAACCR4KMT2ASLC40A1TSHR
SCHEMBL9831055 0.72 PDCD1 (0.38) LMNAEDNRAEDNRBMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0565593-A1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO COMPANY (US) 1993-10-20 EP claimed
EP-0562015-A1 SAFENED HERBICIDAL SULFONAMIDE COMPOSITIONS MONSANTO COMPANY (US) 1993-09-29 EP claimed
WO-1992011761-A1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO COMPANY (US) 1992-07-23 WO claimed
WO-1992010098-A1 SAFENED HERBICIDAL SULFONAMIDE COMPOSITIONS MONSANTO COMPANY (US) 1992-06-25 WO claimed
US-5880066-A COMPOSITION COMPRISING TRIAZOLOPYRIMIDINE SULFONAMIDE HERBICIDE AND OXAZOLIDINE DICHLOROACETAMIDE ANTIDOTE MONSANTO COMPANY (US) 1999-03-09 US disclosed
EP-0565593-B1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO CO (US) 1999-03-03 EP disclosed
US-5484760-A AMIDES MONSANTO COMPANY (US) 1996-01-16 US disclosed
EP-0565593-A1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO COMPANY (US) 1993-10-20 EP disclosed
EP-0562015-A1 SAFENED HERBICIDAL SULFONAMIDE COMPOSITIONS MONSANTO COMPANY (US) 1993-09-29 EP disclosed
WO-1992011761-A1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO COMPANY (US) 1992-07-23 WO disclosed
WO-1992010098-A1 SAFENED HERBICIDAL SULFONAMIDE COMPOSITIONS MONSANTO COMPANY (US) 1992-06-25 WO disclosed
US-4822404-A HERBICIDES THE DOW CHEMICAL COMPANY (US) 1989-04-18 US disclosed
US-4772720-A Process for the preparation of intermediates useful for making herbicidal sulfonamides derived from substituted 2-amino-1,2,4-triazolo(1,5-A)pyrimidines THE DOW CHEMICAL COMPANY (US) 1988-09-20 US disclosed
US-4650892-A ARYLSULFONAMIDE AND DIMETHYL N-CYANODTHIOIMINO CARBONATE THE DOW CHEMICAL COMPANY (US) 1987-03-17 US disclosed
US-4638075-A CHEMICAL INTERMEDIATES FOR TRIAZOLO (1,5A) PYRIMIDINES THE DOW CHEMICAL COMPANY (US) 1987-01-20 US disclosed
EP-0188225-A1 Process for the preparation of herbicidal sulfonamides derived from substituted 2-amino-1,2,4 triazolo (1,5-a) pyrimidines and novel intermediates provided therein THE DOW CHEMICAL COMPANY (US) 1986-07-23 EP disclosed
EP-0150974-A2 Novel sulfonamides derived from substituted 2-amino-1,2,4-triazolo(1,5-a)pyrimidines and compositions and methods of controlling undesired vegetation THE DOW CHEMICAL COMPANY (US) 1985-08-07 EP disclosed