SCHEMBL8359178

SCHEMBL8359178

OP(O)Cc1ccccc1Cc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.50
BCL2 P10415 1/20 0.48
BCL2L1 Q07817 1/20 0.48
CALM1 P0DP23 1/20 0.46
ALOX5 P09917 1/20 0.42
KEAP1 Q14145 1/20 0.41
HPGD P15428 2/20 0.40
MEN1 O00255 1/20 0.40
CYP3A4 P08684 1/20 0.40
ALOX15 P16050 1/20 0.40
KMT2A Q03164 1/20 0.40
HIF1A Q16665 1/20 0.40
HSD17B10 Q99714 1/20 0.40
DAO P14920 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
TSHR P16473 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
HRH1 P35367 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL972711 0.81 CALM1 (0.69) HTR2ABCL2BCL2L1CALM1ALOX5
SCHEMBL2129272 0.76 TSHR (0.48) HTR2ACALM1KEAP1HPGDALOX15
SCHEMBL1773099 0.75 HTR2A (0.56) HTR2ABCL2BCL2L1CALM1ALOX5
SCHEMBL20540578 0.73 CALM1 (0.50) HTR2ABCL2BCL2L1CALM1ALOX5
SCHEMBL30148126 0.71 HTR2A (0.63) HTR2ABCL2BCL2L1CALM1ALOX5
SCHEMBL8871441 0.71 HTR2A (0.63) HTR2ABCL2BCL2L1CALM1ALOX5
SCHEMBL4966037 0.70 BCL2 (0.60) HTR2ABCL2BCL2L1CALM1ALOX5
SCHEMBL695542 0.70 HTR2A (0.56) HTR2ABCL2BCL2L1CALM1ALOX5
SCHEMBL30335116 0.70 KEAP1 (0.75) HTR2ABCL2BCL2L1CALM1ALOX5
SCHEMBL6548117 0.70 HTR2A (0.56) HTR2ABCL2BCL2L1CALM1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5863536-A N-ACETYLATED ALPHA-LINKED ACIDIC DIPEPTIDASE (NAALADASE) ENZYME INHIBITOR FOR THE TREATMENT OF GLUTAMATE ABNORMALITIES AND ASSOCIATED NERVOUS TISSUE ISCHEMIA IN A ANIMAL AND FOR TREATMENT OF PROSTATE DISEASE GUILFORD PHARMACEUTICALS INC. (US) 1999-01-26 US disclosed
US-5795877-A Inhibitors of NAALADase enzyme activity GUILFORD PHARMACEUTICALS INC. (US) 1998-08-18 US disclosed