SCHEMBL8359489

SCHEMBL8359489

O=C(O)c1ccc(C(=O)N(Cc2ccccc2)Cc2ccccc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.69
MEN1 O00255 2/20 0.69
HDAC3 O15379 1/20 0.65
HDAC1 Q13547 1/20 0.65
HDAC7 Q8WUI4 1/20 0.65
HDAC10 Q969S8 1/20 0.65
HDAC8 Q9BY41 1/20 0.65
HDAC6 Q9UBN7 1/20 0.65
CRHBP P24387 1/20 0.65
CRHR2 Q13324 1/20 0.65
LPAR1 Q92633 8/20 0.62
LPAR5 Q9H1C0 8/20 0.62
TSHR P16473 1/20 0.58
TAS2R14 Q9NYV8 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
TDP1 Q9NUW8 1/20 0.56
KDM4E B2RXH2 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8359492 0.94 KMT2A (0.76) KMT2AMEN1HDAC3HDAC1HDAC7
SCHEMBL1003508 0.90 HDAC1 (0.71) KMT2AMEN1HDAC3HDAC1HDAC7
SCHEMBL6843722 0.86 ALDH1A1 (0.68) KMT2AMEN1HDAC3HDAC1HDAC7
SCHEMBL1279153 0.86 LPAR1 (0.77) LPAR1LPAR5TSHRTAS2R14TDP1
Oxalic Acid SCHEMBL29264737 0.86 HDAC1 (0.67) KMT2AMEN1HDAC3HDAC1HDAC7
Oxalic Acid SCHEMBL29264739 0.86 HDAC1 (0.67) KMT2AMEN1HDAC3HDAC1HDAC7
SCHEMBL28778954 0.85 KMT2A (0.65) KMT2AMEN1HDAC3HDAC1HDAC7
SCHEMBL3456064 0.85 KMT2A (0.70) KMT2AMEN1HDAC3HDAC1HDAC7
SCHEMBL28681773 0.85 KMT2A (0.65) KMT2AMEN1HDAC3HDAC1HDAC7
SCHEMBL3450779 0.83 HDAC1 (0.64) KMT2AMEN1HDAC3HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5973076-A MOLDING; CONTROLLING TEMPERATURE IN PRESENCE OF AN AMIDE COMPOUND NEW JAPAN CHEMICAL CO., LTD. (JP) 1999-10-26 US claimed
EP-0776933-B1 Polybutene-1 resin composition and a method of accelerating the crystal transformation NEW JAPAN CHEM CO LTD (JP) 1999-08-04 EP claimed
EP-0776933-A1 Polybutene-1 resin composition and a method of accelerating the crystal transformation NEW JAPAN CHEMICAL CO.,LTD. (JP) 1997-06-04 EP claimed
US-5973076-A MOLDING; CONTROLLING TEMPERATURE IN PRESENCE OF AN AMIDE COMPOUND NEW JAPAN CHEMICAL CO., LTD. (JP) 1999-10-26 US disclosed
EP-0776933-B1 Polybutene-1 resin composition and a method of accelerating the crystal transformation NEW JAPAN CHEM CO LTD (JP) 1999-08-04 EP disclosed
EP-0776933-A1 Polybutene-1 resin composition and a method of accelerating the crystal transformation NEW JAPAN CHEMICAL CO.,LTD. (JP) 1997-06-04 EP disclosed