SCHEMBL8360577

SCHEMBL8360577

C=C(C)C(=O)OCCCNC(=O)CC#N

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 4/20 0.49
TSHR P16473 5/20 0.46
HTT P42858 2/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
HSD17B10 Q99714 1/20 0.46
THRB P10828 1/20 0.40
POLB P06746 1/20 0.37
APEX1 P27695 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALDH1A1 P00352 2/20 0.34
FAAH O00519 1/20 0.33
ACHE P22303 6/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6578464 0.91 MCL1 (0.51) MCL1TSHRHTTLMNAMAPT
SCHEMBL30748187 0.87 THRB (0.50) MCL1TSHRHTTLMNAMAPT
SCHEMBL31616839 0.87 THRB (0.50) MCL1TSHRHTTLMNAMAPT
SCHEMBL16309323 0.84 TSHR (0.55) TSHRHTTTHRBPOLBAPEX1
SCHEMBL16309326 0.82 TSHR (0.53) TSHRHTTLMNATHRBPOLB
SCHEMBL9421255 0.81 TSHR (0.56) TSHRHTTTHRBPOLBAPEX1
SCHEMBL3987446 0.81 MCL1 (0.48) MCL1TSHRHTTLMNAMAPT
SCHEMBL16309329 0.81 TSHR (0.58) TSHRHTTLMNAMAPTTHRB
SCHEMBL16309297 0.81 TSHR (0.53) TSHRHTTLMNATHRBPOLB
SCHEMBL2720435 0.79 TSHR (0.56) TSHRHTTTHRBPOLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5888719-A CONTINING A POLYMER; DARK DECAY STABILITY AGFA-GEVAERT AG (DE) 1999-03-30 US disclosed
US-5518877-A POLYPEPTIDE-ADDITION POLYMER AGFA-GEVAERT AG (DE) 1996-05-21 US disclosed
EP-0671391-A1 5-Vinyl- and 5-ethinyl-quinolinone- and -naphthyridone-carboxylic acids BAYER AG (DE) 1995-09-13 EP disclosed
EP-0666498-A2 Silver halide photographic material Agfa-Gevaert AG (DE) 1995-08-09 EP disclosed
US-4512969-A Compositions containing hydrophobic addenda uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1985-04-23 US disclosed
EP-0077064-B1 PHOTOGRAPHIC ELEMENT COMPRISING A LAYER CONTAINING A CROSS-LINKED POLYMER EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1985-03-27 EP disclosed
US-4420555-A Photographic materials containing yellow filter dyes EASTMAN KODAK COMPANY (US) 1983-12-13 US disclosed
EP-0077064-A1 Photographic element comprising a layer containing a cross-linked polymer EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1983-04-20 EP disclosed
US-4358524-A Polymeric vehicle for metallizable dye image-receiving layer EASTMAN KODAK COMPANY (US) 1982-11-09 US disclosed
US-4304769-A PESTICIDES EASTMAN KODAK COMPANY (US) 1981-12-08 US disclosed
US-4247627-A Photographic elements having hydrophilic colloid layers containing hydrophobic ultraviolet absorbers uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1981-01-27 US disclosed
US-4214047-A Photographic elements having hydrophilic colloid layers containing hydrophobic addenda uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1980-07-22 US disclosed
US-4203716-A Photographic elements having hydrophilic colloid layers containing hydrophobic addenda uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1980-05-20 US disclosed
US-4199363-A Processes for achieving uniform, efficient distribution of hydrophobic materials through hydrophilic colloid layers and loaded latex compositions EASTMAN KODAK COMPANY (US) 1980-04-22 US disclosed
US-4133687-A Photographic elements having hydrophilic colloid layers containing compounds having activator precursors and hydrophobic developing agents uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1979-01-09 US disclosed