SCHEMBL6578464

SCHEMBL6578464

C=C(C)C(=O)OCCNC(=O)CC#N

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 4/20 0.51
THRB P10828 1/20 0.42
TSHR P16473 4/20 0.41
HTT P42858 2/20 0.37
HSD17B10 Q99714 2/20 0.37
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
ALDH1A1 P00352 6/20 0.36
POLB P06746 1/20 0.33
APEX1 P27695 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
KDM4E B2RXH2 2/20 0.31
CYP3A4 P08684 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31616839 0.92 THRB (0.50) MCL1THRBTSHRHTTHSD17B10
SCHEMBL30748187 0.92 THRB (0.50) MCL1THRBTSHRHTTHSD17B10
SCHEMBL8360577 0.91 MCL1 (0.49) MCL1THRBTSHRHTTHSD17B10
SCHEMBL22847851 0.86 MCL1 (0.50) MCL1THRBTSHRHTTHSD17B10
SCHEMBL3987446 0.83 MCL1 (0.48) MCL1THRBTSHRHTTHSD17B10
SCHEMBL14345594 0.83 THRB (0.50) THRBTSHRHTTALDH1A1POLB
SCHEMBL16309307 0.81 THRB (0.48) THRBTSHRHTTALDH1A1POLB
SCHEMBL9109443 0.80 THRB (0.44) THRBTSHRHTTALDH1A1POLB
SCHEMBL4917590 0.80 THRB (0.47) THRBTSHRHTTALDH1A1POLB
SCHEMBL8430137 0.80 THRB (0.47) THRBTSHRHTTHSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624214-B2 Polymerizable absorbers of UV and high energy visible light JOHNSON & JOHNSON VISION CARE, INC. (US) 2026-05-12 US disclosed
US-20260109796-A1 MATERIALS AND METHODS FOR LIGHT ADJUSTABLE OPHTHALMIC DEVICES JOHNSON & JOHNSON SURGICAL VISION INC (US) 2026-04-23 US disclosed
US-20260110920-A1 MATERIALS AND METHODS FOR LIGHT ADJUSTABLE OPHTHALMIC DEVICES JOHNSON & JOHNSON SURGICAL VISION INC (US) 2026-04-23 US disclosed
US-12595370-B2 Polymerizable absorbers of UV and high energy visible light JOHNSON & JOHNSON VISION CARE, INC. (US) 2026-04-07 US disclosed
US-12595371-B2 Contact lens with improved vision break-up time JOHNSON & JOHNSON VISION CARE, INC. (US) 2026-04-07 US disclosed
EP-4707342-A2 CONTACT LENS DISPLAYING IMPROVED VISION ATTRIBUTES Johnson & Johnson Vision Care, Inc. (US) 2026-03-11 EP disclosed
US-20260062386-A1 POLYMERIZABLE FUSED TRICYCLIC COMPOUNDS AS ABSORBERS OF UV AND VISIBLE LIGHT JOHNSON & JOHNSON VISION CARE (US) 2026-03-05 US disclosed
US-20260044018-A1 MULTIFOCAL CONTACT LENS DISPLAYING IMPROVED VISION ATTRIBUTES JOHNSON & JOHNSON VISION CARE (US) 2026-02-12 US disclosed
US-12534623-B2 Contact lens with improved tear film optical quality JOHNSON & JOHNSON VISION CARE, INC. (US) 2026-01-27 US disclosed
US-20260003209-A1 TORIC CONTACT LENS DISPLAYING IMPROVED VISION ATTRIBUTES JOHNSON & JOHNSON VISION CARE (US) 2026-01-01 US disclosed
EP-0077064-B1 PHOTOGRAPHIC ELEMENT COMPRISING A LAYER CONTAINING A CROSS-LINKED POLYMER EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1985-03-27 EP disclosed
US-4420555-A Photographic materials containing yellow filter dyes EASTMAN KODAK COMPANY (US) 1983-12-13 US disclosed
EP-0077064-A1 Photographic element comprising a layer containing a cross-linked polymer EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1983-04-20 EP disclosed
US-4358524-A Polymeric vehicle for metallizable dye image-receiving layer EASTMAN KODAK COMPANY (US) 1982-11-09 US disclosed
US-4304769-A PESTICIDES EASTMAN KODAK COMPANY (US) 1981-12-08 US disclosed
US-4247627-A Photographic elements having hydrophilic colloid layers containing hydrophobic ultraviolet absorbers uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1981-01-27 US disclosed
US-4214047-A Photographic elements having hydrophilic colloid layers containing hydrophobic addenda uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1980-07-22 US disclosed
US-4203716-A Photographic elements having hydrophilic colloid layers containing hydrophobic addenda uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1980-05-20 US disclosed
US-4199363-A Processes for achieving uniform, efficient distribution of hydrophobic materials through hydrophilic colloid layers and loaded latex compositions EASTMAN KODAK COMPANY (US) 1980-04-22 US disclosed
US-4133687-A Photographic elements having hydrophilic colloid layers containing compounds having activator precursors and hydrophobic developing agents uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1979-01-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12595370-B2 Polymerizable absorbers of UV and high energy visible light NLRP3, NLRP1, XDH MCL1 4833/4885THRB 372/4885TSHR 980/4885
US-20260044018-A1 MULTIFOCAL CONTACT LENS DISPLAYING IMPROVED VISION ATTRIBUTES NECTIN4, CRYAB, PSEN1 MCL1 4461/4885THRB 2635/4885TSHR 3224/4885
US-20260110920-A1 MATERIALS AND METHODS FOR LIGHT ADJUSTABLE OPHTHALMIC DEVICES ERCC1, ERCC5, ERCC4 MCL1 4636/4885THRB 3423/4885TSHR 2920/4885
US-20260003209-A1 TORIC CONTACT LENS DISPLAYING IMPROVED VISION ATTRIBUTES TRPA1, LATS2, TEC MCL1 4694/4885THRB 1110/4885TSHR 663/4885
US-20260062386-A1 POLYMERIZABLE FUSED TRICYCLIC COMPOUNDS AS ABSORBERS OF UV AND VISIBLE LIGHT ERCC1, MCM6, GPR6 MCL1 4777/4885THRB 1569/4885TSHR 1295/4885
US-20260109796-A1 MATERIALS AND METHODS FOR LIGHT ADJUSTABLE OPHTHALMIC DEVICES ERCC1, PDE6H, HCK MCL1 4027/4885THRB 2342/4885TSHR 1585/4885
US-12595371-B2 Contact lens with improved vision break-up time CUTA, VEGFA, CASP14 MCL1 4649/4885THRB 976/4885TSHR 3672/4885
US-12624214-B2 Polymerizable absorbers of UV and high energy visible light CRY1, SCNN1G, MALT1 MCL1 4196/4885THRB 424/4885TSHR 832/4885
US-12534623-B2 Contact lens with improved tear film optical quality CUTA, CRYAA, TCOF1 MCL1 4692/4885THRB 1083/4885TSHR 1988/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.