Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | KDM1A | O60341 | 5/20 | 0.58 |
| ▸ | MAOA | P21397 | 4/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL728209 | 0.88 | KDM1A (0.72) | MEN1KMT2AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8360649 | 0.84 | KDM1A (0.66) | KMOMEN1KMT2AMAPTKDM4E | |
| SCHEMBL8356755 | 0.82 | KDM1A (0.67) | KMOMEN1KMT2AMAPTKDM4E | |
| SCHEMBL424256 | 0.82 | KMO (1.00) | KMOMEN1KMT2AMAPTKDM4E | |
| SCHEMBL29379527 | 0.82 | KMO (1.00) | KMOMEN1KMT2AMAPTKDM4E | |
| SCHEMBL424785 | 0.81 | KMO (0.87) | KMOMEN1KMT2AMAPTLMNA | |
| SCHEMBL8356715 | 0.78 | MEN1 (0.66) | KMOMEN1KMT2AMAPTKDM4E | |
| SCHEMBL8357248 | 0.78 | MEN1 (0.56) | KMOMEN1KMT2AMAPTMAPK1 | |
| SCHEMBL12297881 | 0.78 | ALOX5 (0.67) | MEN1KMT2AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL2763474 | 0.77 | KDM1A (0.79) | MEN1KMT2AMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877193-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-02 | — | — | US | claimed |
| US-5958910-A | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5877193-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0819681-A2 | N-(4-Aryl-thiazol-2-yl)-sulfonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-21 | — | — | EP | disclosed |