Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 2/20 | 0.48 |
| ▸ | STS | P08842 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363938 | 0.92 | CNR1 (0.46) | MEN1KMT2AMAPTTP53KDM4E | |
| SCHEMBL8363935 | 0.92 | MEN1 (0.46) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL8363172 | 0.91 | MEN1 (0.43) | NR1D1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL8363933 | 0.91 | KMT2A (0.54) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL8363828 | 0.91 | HDAC6 (0.44) | STSMEN1KMT2APSEN1PSEN2 | |
| SCHEMBL8360879 | 0.89 | JAK2 (0.51) | NR1D1STSMEN1KMT2APSEN1 | |
| SCHEMBL8363192 | 0.89 | NR1D1 (0.45) | NR1D1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL8363840 | 0.89 | RORC (0.48) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL8364270 | 0.89 | PSEN1 (0.44) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL8363917 | 0.89 | MEN1 (0.45) | MEN1KMT2APSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003013527-A1 | SULFONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |