Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.70 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.70 |
| ▸ | ESRRG | P62508 | 14/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | ESRRB | O95718 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362685 | 1.00 | ESR1 (0.70) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL8362684 | 1.00 | ESR1 (0.70) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL5738427 | 0.95 | ESR1 (0.79) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL8362668 | 0.95 | ESR1 (0.79) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL5738276 | 0.95 | ESR1 (0.79) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL8362672 | 0.95 | ESR1 (0.79) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL8362664 | 0.95 | ESR1 (0.79) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL5738281 | 0.95 | ESR1 (0.79) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL8500711 | 0.92 | ESR1 (0.61) | ESR1CYP19A1ESR2ESRRGLMNA | |
| SCHEMBL5737939 | 0.88 | LMNA (0.71) | ESR1CYP19A1ESR2ESRRGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779808-B1 | TRIPHENYLETHYLENES FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS | ORION YHTYMAE OY (FI) | 1999-08-18 | — | — | EP | disclosed |
| US-5912273-A | COMPOUNDS WITH CHLORO AND HYDROXY GROUPS FOR OSTEOPOROSIS | ORION-YHTYMA OY (FI) | 1999-06-15 | — | — | US | disclosed |
| US-5750576-A | BONE DISORDERS | ORION-YHTYMA OY (FI) | 1998-05-12 | — | — | US | disclosed |
| EP-0779808-A1 | TRIPHENYLETHYLENES FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS | ORION-YHTYMÄ OY (FI) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007402-A1 | TRIPHENYLETHYLENES FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS | Orion-Yhtymä Oy (FI) | 1996-03-14 | — | — | WO | disclosed |