Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 7/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874650 | 0.84 | METAP1 (0.57) | METAP1CYP19A1ACHEHTR1ADRD2 | |
| SCHEMBL9431516 | 0.83 | CYP19A1 (0.56) | METAP1CYP19A1ACHEHTR1ADRD2 | |
| SCHEMBL8873256 | 0.81 | METAP1 (0.58) | METAP1CYP19A1ACHEHTR1ADRD2 | |
| SCHEMBL8873261 | 0.81 | METAP1 (0.58) | METAP1CYP19A1ACHEHTR1ADRD2 | |
| SCHEMBL8873267 | 0.81 | METAP1 (0.58) | METAP1CYP19A1ACHEHTR1ADRD2 | |
| SCHEMBL8875391 | 0.80 | ACHE (0.53) | METAP1CYP19A1ACHEHTR1AHTR2C | |
| SCHEMBL8594813 | 0.80 | TYRO3 (0.43) | METAP1CYP19A1ACHEHTR1ADRD2 | |
| SCHEMBL8873394 | 0.80 | TYRO3 (0.43) | METAP1CYP19A1ACHEHTR1ADRD2 | |
| SCHEMBL28949987 | 0.79 | METAP1 (0.51) | METAP1CYP19A1ACHEHTR1ADRD2 | |
| SCHEMBL15617634 | 0.78 | METAP1 (0.62) | METAP1CYP19A1ACHEHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699909-B1 | MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS | PRESCIENT NEUROPHARMA INC. (CA) | 2004-03-02 | — | — | US | disclosed |