Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.58 |
| ▸ | ACHE | P22303 | 7/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8873256 | 1.00 | METAP1 (0.58) | METAP1ACHECYP19A1HTR2CHTR1A | |
| SCHEMBL8873267 | 1.00 | METAP1 (0.58) | METAP1ACHECYP19A1HTR2CHTR1A | |
| SCHEMBL8596739 | 0.82 | TYRO3 (0.40) | METAP1ACHECYP19A1 | |
| SCHEMBL8596737 | 0.82 | TYRO3 (0.40) | METAP1ACHECYP19A1 | |
| SCHEMBL8874229 | 0.82 | TYRO3 (0.40) | METAP1ACHECYP19A1 | |
| SCHEMBL8364658 | 0.81 | METAP1 (0.61) | METAP1ACHECYP19A1HTR2CHTR1A | |
| SCHEMBL28949987 | 0.81 | METAP1 (0.51) | METAP1ACHECYP19A1HTR2CHTR1A | |
| SCHEMBL8595392 | 0.80 | METAP1 (0.59) | METAP1ACHEHTR2CHTR2AHTR2B | |
| SCHEMBL8873299 | 0.80 | METAP1 (0.59) | METAP1ACHEHTR2CHTR2AHTR2B | |
| SCHEMBL8595390 | 0.80 | METAP1 (0.59) | METAP1ACHEHTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0657426-A2 | Tricyclic pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |