Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | STS | P08842 | 5/20 | 0.51 |
| ▸ | ESR1 | P03372 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.50 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220231 | 0.87 | LMNA (0.59) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL2738492 | 0.87 | LMNA (0.59) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8366649 | 0.86 | LMNA (0.69) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL21276838 | 0.86 | LMNA (0.69) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL2760327 | 0.86 | LMNA (0.69) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL218799 | 0.85 | HSD17B1 (0.57) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL219379 | 0.85 | HSD17B1 (0.57) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL2738534 | 0.84 | LMNA (0.64) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8370295 | 0.83 | LMNA (0.65) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL218663 | 0.83 | LMNA (0.65) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0712412-B1 | 15,15-DIALKYL-SUBSTITUTED DERIVATIVES OF ESTRADIOL | SCHERING AG (DE) | 1999-01-07 | — | — | EP | disclosed |
| US-5656622-A | 15,15-dialkyl-substituted derivatives of estradiol | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-08-12 | — | — | US | disclosed |
| US-5587496-A | HIGH ESTROGENIC EFFECTIVENESS; CAN BE USED FOR TREATING ESTROGEN DEFICIENCY SYMPTOMS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-12-24 | — | — | US | disclosed |
| WO-1995004070-A1 | 15,15-DIALKYL-SUBSTITUTED DERIVATIVES OF ESTRADIOL | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-02-09 | — | — | WO | disclosed |