Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.41 |
| ▸ | ITGAV | P06756 | 13/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.40 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 9/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14585780 | 0.96 | ITGB3 (0.38) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL7738161 | 0.93 | KEAP1 (0.44) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL14585799 | 0.91 | ITGB3 (0.40) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL8366358 | 0.90 | ITGB3 (0.40) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL7746128 | 0.89 | KDM4A (0.43) | ITGB3ITGAVITGB1ITGA5KEAP1 | |
| SCHEMBL14585800 | 0.89 | KDM4A (0.43) | ITGB3ITGAVITGB1ITGA5KEAP1 | |
| SCHEMBL7738154 | 0.89 | KDM4A (0.43) | ITGB3ITGAVITGB1ITGA5KEAP1 | |
| SCHEMBL14585787 | 0.88 | ITGB3 (0.41) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL14585786 | 0.87 | ITGB3 (0.40) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL7738586 | 0.87 | ITGB3 (0.40) | ITGB3ITGAVITGB1ITGA5ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6537520-B1 | Diagnosis and treatment of cancer; kit containing compound having peptide or peptidomimetic functionality that binds to a alpha v beta 3 receptor linked to a chelator | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-03-25 | — | — | US | disclosed |