Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.36 |
| ▸ | KDM6B | O15054 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30440354 | 1.00 | KDM4C (0.36) | KDM4CKDM6BALDH1A1KDM4EMEN1 | |
| SCHEMBL27791683 | 0.87 | KDM4C (0.37) | KDM4CKDM6BALDH1A1KDM4EMEN1 | |
| SCHEMBL3655338 | 0.85 | SIRT3 (0.38) | KDM4CKDM6BALDH1A1KDM4EMEN1 | |
| SCHEMBL29623343 | 0.85 | SIRT3 (0.38) | KDM4CKDM6BALDH1A1KDM4EMEN1 | |
| SCHEMBL980578 | 0.77 | MAOA (0.35) | ALDH1A1MAPTL3MBTL1NAPRTGAA | |
| SCHEMBL29816130 | 0.77 | MAOA (0.35) | ALDH1A1MAPTL3MBTL1NAPRTGAA | |
| Hydrochloric Acid SCHEMBL27489771 | 0.76 | BLM (0.34) | ALDH1A1MAPTNAPRTGAATSHR | |
| Hydrochloric Acid SCHEMBL3719374 | 0.76 | BLM (0.34) | ALDH1A1MAPTNAPRTGAATSHR | |
| SCHEMBL27794715 | 0.73 | ALDH1A1 (0.33) | ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL2878522 | 0.73 | JAK2 (0.38) | MKNK2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023056951-A1 | ARYL-SUBSTITUTED HETEROCYCLIC COMPOUND | 杭州德睿智药科技有限公司 | 2023-04-13 | — | — | WO | disclosed |
| CN-110511219-A | The dihydronaphthridine class compound and application thereof that phenyl replaces | GUANGDONG HEC PHARMACEUTICAL | 2019-11-29 | — | — | CN | disclosed |
| CN-101641352-B | Substituted 4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof | BAYER HEALTHCARE AG DE | 2013-11-20 | — | — | CN | disclosed |
| CN-101641352-A | Substituted 4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof | BAYER HEALTHCARE AG (DE) | 2010-02-03 | — | — | CN | disclosed |
| EP-0831869-A4 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS IN (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0831869-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | Elizanor Biopharmaceuticals, Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040190-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |