Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 12/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | KDM4D | Q6B0I6 | 5/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348613 | 1.00 | SIRT2 (0.46) | SIRT2KCNA3KDM4DCKS1BSKP1 | |
| SCHEMBL6335174 | 0.93 | KCNA3 (0.43) | SIRT2KCNA3KDM4DCKS1BSKP1 | |
| SCHEMBL6335407 | 0.93 | KCNA3 (0.43) | SIRT2KCNA3KDM4DCKS1BSKP1 | |
| SCHEMBL6326986 | 0.93 | KCNA3 (0.43) | SIRT2KCNA3KDM4DCKS1BSKP1 | |
| SCHEMBL8364805 | 0.89 | SIRT2 (0.47) | SIRT2 | |
| SCHEMBL6324984 | 0.89 | SIRT2 (0.41) | SIRT2KCNA3KDM4D | |
| SCHEMBL6329501 | 0.83 | CTSL (0.46) | SIRT2 | |
| SCHEMBL8363823 | 0.81 | KDM4D (0.43) | KDM4D | |
| SCHEMBL8347758 | 0.80 | SIRT2 (0.55) | SIRT2 | |
| SCHEMBL8364700 | 0.80 | SIRT2 (0.55) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003061653-A1 | 3-(IMIDAZOLYL)-2-AMINOPROPANOIC ACIDS FOR USE AS TAFI-A INHIBITORS FOR THE TREATMENT OF THROMBOTIC DISEASES | PFIZER LIMITED (GB) | 2003-07-31 | — | — | WO | disclosed |