Tetrahydrocortisone

Tetrahydrocortisone

SCHEMBL8366487

C[C@]12CC[C@@H](O)C[C@H]1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.[AlH3]

nearest known ligand 0.77

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
G6PD P11413 4/20 0.77
CYP3A4 P08684 4/20 0.76
GABRA1 P14867 5/20 0.57
GABRB2 P47870 5/20 0.57
GABRG2 P18507 3/20 0.57
GABRB3 P28472 3/20 0.57
GABRA2 P47869 3/20 0.57
CYP2C9 P11712 2/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
GLA P06280 1/20 0.57
HSD17B10 Q99714 6/20 0.53
LMNA P02545 2/20 0.53
ALDH1A1 P00352 2/20 0.53
NR3C1 P04150 2/20 0.53
SERPINA6 P08185 2/20 0.53
CYP2D6 P10635 1/20 0.53
TSHR P16473 1/20 0.53
SHBG P04278 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrocortisone SCHEMBL1184193 0.99 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL1184192 0.99 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL5610354 0.99 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL1332665 0.99 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL193711 0.99 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL4111245 0.99 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL5139991 0.98 G6PD (0.77) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL6232115 0.98 G6PD (0.77) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL11169159 0.98 G6PD (0.77) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL6461669 0.98 G6PD (0.77) G6PDCYP3A4GABRA1GABRB2GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11003890-A None JP disclosed
JP-H113890-A SEMICONDUCTOR INTEGRATED CIRCUIT DEVICE AND ITS MANUFACTURE HITACHI LTD 1999-01-06 JP disclosed