SCHEMBL8366646

SCHEMBL8366646

CS(=O)(=O)O.CS(=O)(=O)O.OC1CCC(O)CC1

nearest known ligand 0.43

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.43
TSHR P16473 2/20 0.39
CA2 P00918 3/20 0.37
SHBG P04278 1/20 0.36
TP53 P04637 1/20 0.32
CYP3A4 P08684 2/20 0.32
LMNA P02545 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRG2 P18507 1/20 0.32
NFKB1 P19838 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA5 P31644 1/20 0.32
GABRA3 P34903 1/20 0.32
GABRA2 P47869 1/20 0.32
GABRA6 Q16445 1/20 0.32
CA12 O43570 3/20 0.32
CA7 P43166 1/20 0.32
CA14 Q9ULX7 1/20 0.32
KDM4E B2RXH2 1/20 0.31
CA5A P35218 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cyclohexanol SCHEMBL3916391 0.85 TSHR (0.56) EPHX2TSHRCA2CYP3A4LMNA
SCHEMBL6628487 0.81 TSHR (0.35) EPHX2TSHRMAPK1
SCHEMBL20594856 0.79 EPHX2 (0.33) EPHX2TSHRSHBG
SCHEMBL3053305 0.79 EPHX2 (0.33) EPHX2TSHRSHBG
SCHEMBL3053304 0.79 EPHX2 (0.33) EPHX2TSHRSHBG
SCHEMBL12018141 0.79 CA12 (0.46) EPHX2CA2LMNACA12CA7
SCHEMBL12017951 0.79 CA12 (0.46) EPHX2CA2LMNACA12CA7
SCHEMBL11784035 0.75 TSHR (0.52) EPHX2TSHRCYP3A4LMNAGABRA1
SCHEMBL24511672 0.75 CA1 (0.34) EPHX2TSHRCA2SHBGCA1
Ethane SCHEMBL18543108 0.73 TSHR (0.54) EPHX2TSHRCA2SHBGLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0918781-A4 ASYMMETRIC SYNTHESIS CATALYZED BY TRANSITION METAL COMPLEXES WITH CYCLIC CHIRAL LIGANDS PENN STATE RES FOUND (US) 1999-07-28 EP disclosed
EP-0918781-A1 ASYMMETRIC SYNTHESIS CATALYZED BY TRANSITION METAL COMPLEXES WITH CYCLIC CHIRAL LIGANDS THE PENN STATE RESEARCH FOUNDATION (US) 1999-06-02 EP disclosed
WO-1997047633-A1 ASYMMETRIC SYNTHESIS CATALYZED BY TRANSITION METAL COMPLEXES WITH CYCLIC CHIRAL PHOSPHINE LIGANDS THE PENN STATE RESEARCH FOUNDATION (US) 1997-12-18 WO disclosed