Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 6/20 | 0.52 |
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | DRD3 | P35462 | 5/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9029311 | 0.90 | KCNA3 (0.53) | HTR1BHTR1DDRD4DRD2DRD3 | |
| SCHEMBL19272084 | 0.86 | HTR1B (0.53) | HTR1BHTR1DDRD4DRD2DRD3 | |
| SCHEMBL7751165 | 0.83 | KDM4E (0.66) | HTR1BHTR1DDRD4DRD2DRD3 | |
| Bromide SCHEMBL5935418 | 0.80 | LTA4H (0.50) | HTR1BHTR1DDRD4DRD2DRD3 | |
| SCHEMBL12355563 | 0.79 | HTR1B (0.49) | HTR1BHTR1DDRD4DRD2DRD3 | |
| SCHEMBL8099108 | 0.79 | HTR1B (0.56) | HTR1BHTR1DDRD4DRD2DRD3 | |
| SCHEMBL10246762 | 0.78 | HTR1B (0.63) | HTR1BHTR1DDRD4DRD2DRD3 | |
| SCHEMBL5511560 | 0.77 | CASR (0.67) | DRD4DRD2DRD3ALDH1A1 | |
| SCHEMBL11113648 | 0.76 | CYP2D6 (0.43) | HTR1BHTR1DMTNR1AMTNR1BKDM4E | |
| SCHEMBL7913813 | 0.75 | CYP2D6 (0.56) | HTR1BHTR1DDRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6680324-B2 | 4-AMINO-6-PHENYL-PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2004-01-20 | — | — | US | disclosed |