SCHEMBL8367185

SCHEMBL8367185

Cc1c(C(N)=O)nn(Cc2ccc(Cl)c(Cl)c2)c1-c1ccc(Cl)cc1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 8/20 0.45
CNR1 P21554 5/20 0.45
GCGR P47871 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.43
GALR3 O60755 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
NR2F2 P24468 1/20 0.43
HIF1A Q16665 1/20 0.43
MEN1 O00255 1/20 0.41
MAPT P10636 1/20 0.41
KMT2A Q03164 1/20 0.41
POLB P06746 1/20 0.40
CYP19A1 P11511 2/20 0.40
TSHR P16473 1/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8368130 0.92 CNR2 (0.44) CNR2CNR1GCGRSMN1; SMN2GALR3
SCHEMBL8368098 0.90 CNR1 (0.50) CNR2CNR1SMN1; SMN2CYP2C9MAPT
SCHEMBL8366436 0.90 GCGR (0.46) CNR2CNR1GCGRCYP19A1PTGDR2
SCHEMBL8369103 0.90 GCGR (0.48) CNR2CNR1GCGRSMN1; SMN2CYP2C9
Hydrochloric Acid SCHEMBL8366437 0.89 GCGR (0.47) CNR2CNR1GCGRSMN1; SMN2CYP2C9
SCHEMBL8366420 0.86 CYP19A1 (0.55) CNR1GCGRSMN1; SMN2MEN1MAPT
SCHEMBL8364640 0.83 CNR2 (0.51) CNR2CNR1SMN1; SMN2CYP3A4CYP2C9
SCHEMBL8369230 0.82 CNR1 (0.57) CNR2CNR1SMN1; SMN2CYP3A4CYP2C9
SCHEMBL8369838 0.82 GCGR (0.45) CNR2CNR1GCGRCYP19A1PTGDR2
SCHEMBL8368084 0.82 CCR2 (0.47) CNR2CNR1GCGRSMN1; SMN2CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5925768-A ANTIINFLAMMATORY AGENTS; ANALGESICS, ANTICOAGULANTS, NARCOTICS SANOFI (FR) 1999-07-20 US disclosed