SCHEMBL8364640

SCHEMBL8364640

Cc1c(C(N)=O)nn(Cc2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 8/20 0.51
CNR1 P21554 2/20 0.51
SLC16A3 O15427 2/20 0.48
SLC16A1 P53985 2/20 0.48
MCTS1 Q9ULC4 2/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
TSHR P16473 1/20 0.48
PMP22 Q01453 1/20 0.48
HIF1A Q16665 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
JAK2 O60674 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
TP53 P04637 1/20 0.47
HTT P42858 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8369778 0.89 CYP1A2 (0.58) CNR2CNR1SLC16A3SLC16A1MCTS1
SCHEMBL8368073 0.85 CYP19A1 (0.51) CNR2CNR1SLC16A3SLC16A1MCTS1
SCHEMBL8367185 0.83 CNR2 (0.45) CNR2CNR1CYP3A4CYP2C9TSHR
SCHEMBL8368130 0.82 CNR2 (0.44) CNR2CNR1CYP3A4CYP2C9TSHR
SCHEMBL8366585 0.78 PPARG (0.41) CNR2SLC16A3SLC16A1MCTS1CYP1A2
SCHEMBL29388169 0.77 CNR2 (0.77) CNR2CNR1
SCHEMBL922969 0.77 CNR2 (0.77) CNR2CNR1
SCHEMBL14627389 0.75 CYP1A2 (0.55) SLC16A3SLC16A1MCTS1CYP1A2CYP3A4
SCHEMBL8366607 0.75 MARS1 (0.52) SLC16A3SLC16A1MCTS1CYP1A2CYP3A4
SCHEMBL14584132 0.74 CYP1A2 (0.80) CYP1A2CYP3A4CYP2D6CYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5925768-A ANTIINFLAMMATORY AGENTS; ANALGESICS, ANTICOAGULANTS, NARCOTICS SANOFI (FR) 1999-07-20 US disclosed