SCHEMBL8367477

SCHEMBL8367477

CC(=O)Nc1cc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)ccn1

nearest known ligand 0.83

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8367482 1.00 BDKRB2 (0.83) BDKRB2
Fr-173657 SCHEMBL29473494 0.91 BDKRB2 (1.00) BDKRB2
Fr-173657 SCHEMBL3718364 0.91 BDKRB2 (1.00) BDKRB2
Fr-173657 SCHEMBL1559539 0.91 BDKRB2 (1.00) BDKRB2
Fr-173657 SCHEMBL7246238 0.90 BDKRB2 (0.99) BDKRB2
Fr-173657 SCHEMBL7246230 0.90 BDKRB2 (0.99) BDKRB2
SCHEMBL8361832 0.89 BDKRB2 (0.82) BDKRB2
SCHEMBL8361829 0.89 BDKRB2 (0.82) BDKRB2
SCHEMBL7748660 0.89 BDKRB2 (1.00) BDKRB2
SCHEMBL7748662 0.89 BDKRB2 (1.00) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994368-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
EP-0807105-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-11-19 EP disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 WO disclosed