Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | CCKBR | P32239 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500008 | 0.86 | HSD17B10 (0.41) | EGFRBCHEHSD17B10BDKRB1 | |
| SCHEMBL9586168 | 0.84 | EGFR (0.48) | EGFRBCHE | |
| SCHEMBL3958089 | 0.83 | EGFR (0.47) | EGFRTP53L3MBTL1PPARDCCKBR | |
| SCHEMBL2605809 | 0.83 | EGFR (0.47) | EGFRTP53L3MBTL1PPARDCCKBR | |
| SCHEMBL3964364 | 0.83 | EGFR (0.47) | EGFRTP53L3MBTL1PPARDCCKBR | |
| SCHEMBL6244927 | 0.83 | SMN1; SMN2 (0.51) | HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL9124959 | 0.82 | EGFR (0.50) | EGFRBCHEALDH1A1SMN1; SMN2 | |
| SCHEMBL5410564 | 0.80 | PARP3 (0.43) | EGFRFFAR1TP53L3MBTL1PPARD | |
| SCHEMBL3694236 | 0.80 | BCHE (0.39) | BCHECCKBRBDKRB1 | |
| SCHEMBL26644922 | 0.80 | CYP1A2 (0.47) | L3MBTL1BCHEHSD17B10ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105934246-A | Tetrahydroquinoline compositions as BET bromodomain inhibitors | 福马疗法公司 | 2016-09-07 | — | — | CN | claimed |
| CN-105934246-A | Tetrahydroquinoline compositions as BET bromodomain inhibitors | 福马疗法公司 | 2016-09-07 | — | — | CN | disclosed |
| WO-1999051590-A1 | SUBSTITUTED INDOLINONES AS KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-14 | — | — | WO | disclosed |
| EP-0364327-B1 | QUINOLINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPY | SYNTHELABO (FR) | 1992-01-15 | — | — | EP | disclosed |
| EP-0364327-A1 | Quinolinone derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1990-04-18 | — | — | EP | disclosed |