Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.61 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
| ▸ | KMO | O15229 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | DDT | P30046 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.46 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.46 |
| ▸ | CD74 | P04233 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26365859 | 0.85 | FOLH1 (0.62) | FOLH1KMOPTGER1PLA2G2APTGER4 | |
| SCHEMBL22442327 | 0.85 | FOLH1 (0.62) | FOLH1KMOPTGER1PLA2G2APTGER4 | |
| SCHEMBL2213546 | 0.82 | KMO (0.73) | FOLH1KMOPTGER1NR1H4RXRA | |
| SCHEMBL30259065 | 0.82 | KMO (0.73) | FOLH1KMOPTGER1NR1H4RXRA | |
| SCHEMBL27378863 | 0.82 | ROCK2 (0.60) | DPP4ROCK2 | |
| SCHEMBL7919905 | 0.81 | DPP4 (0.66) | FOLH1DPP4RXRARXRB | |
| SCHEMBL1707626 | 0.81 | KMO (0.70) | FOLH1KMOPTGER1NR1H4RXRA | |
| Bicarbonate SCHEMBL27817695 | 0.81 | DPP4 (0.83) | FOLH1DPP4PTGER1PTGER4PTGER3 | |
| SCHEMBL382724 | 0.81 | KMO (0.70) | FOLH1KMOPTGER1NR1H4RXRA | |
| SCHEMBL8111002 | 0.80 | FOLH1 (0.57) | FOLH1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794789-A4 | INHIBITORS OF PRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 1999-05-26 | — | — | EP | claimed |
| EP-0794789-A1 | INHIBITORS OF PRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1997-09-17 | — | — | EP | claimed |
| WO-1996021456-A1 | INHIBITORS OF PRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1996-07-18 | — | — | WO | claimed |
| CN-1080257-C | Guanidine derivatives as inhibitors of Na+/H+ exchange in cells | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | CN | disclosed |
| CN-1123545-A | Guanidine derivatives as inhibitors of Na+/H+ exchange in cells | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-05-29 | — | — | CN | disclosed |