SCHEMBL8368595

SCHEMBL8368595

O=c1ccc2ccccc2c2c1C=CC2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PAX8 Q06710 1/20 0.47
TDP1 Q9NUW8 2/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
HPGD P15428 4/20 0.40
CYP1A2 P05177 3/20 0.40
CYP2C19 P33261 3/20 0.40
KDM4E B2RXH2 3/20 0.40
HSD17B10 Q99714 2/20 0.40
CYP2C9 P11712 2/20 0.40
GLA P06280 1/20 0.40
SIRT1 Q96EB6 1/20 0.40
HPRT1 P00492 1/20 0.40
ALDH1A1 P00352 4/20 0.38
CYP2A6 P11509 1/20 0.38
TSHR P16473 1/20 0.38
MEN1 O00255 1/20 0.38
USP2 O75604 1/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
CYP2D6 P10635 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6249376 0.75 CYP1A2 (0.49) PAX8TDP1L3MBTL1HPGDCYP1A2
SCHEMBL29399101 0.73 HSD17B10 (0.44) PAX8TDP1L3MBTL1HPGDCYP1A2
SCHEMBL2290546 0.73 HSD17B10 (0.44) PAX8TDP1L3MBTL1HPGDCYP1A2
Benzene SCHEMBL1724439 0.72 HSD17B10 (0.42) PAX8TDP1L3MBTL1HPGDCYP1A2
SCHEMBL31450268 0.72 HSD17B10 (0.42) PAX8TDP1L3MBTL1HPGDCYP1A2
SCHEMBL2968049 0.71 ALDH1A1 (0.38) HPGDCYP1A2CYP2C19KDM4EHSD17B10
SCHEMBL3258162 0.71 ALDH1A1 (0.41) PAX8TDP1L3MBTL1HPGDCYP1A2
SCHEMBL29563614 0.71 ALDH1A1 (0.41) PAX8TDP1L3MBTL1HPGDCYP1A2
SCHEMBL4405538 0.71 ERN1 (0.41) TDP1CYP1A2KDM4EALDH1A1CYP2A6
SCHEMBL29181691 0.71 ALDH1A1 (0.49) PAX8TDP1L3MBTL1HPGDCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888292-A1 TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY $g(a)v$g(b)3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME HOECHST MARION ROUSSEL (FR) 1999-01-07 EP disclosed
WO-1997034865-A1 TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY αvβ3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME HOECHST MARION ROUSSEL (FR) 1997-09-25 WO disclosed